Abstract：Objective：To observe the clinical effect of Qufeng Tongluo prescription in assisted treatment of acute cerebral infarction of wind- phlegm obstructing the collaterals type. Methods： A total of 80 cases of patients with acute cerebral infarction of wind- phlegm obstructing the collaterals type were selected and divided into the observation group and the control group according to the random number table method，40 cases in each group. The control group was given routine treatment scheme，and the observation group was additionally given Qufeng Tongluo prescription based on the treatment of the control group. The clinical effect，scores of National Institutes of Health Stroke Scale(NIHSS)，modified Rankin Scale(mRS)， and Fugl-Meyer Assessment(FMA)，and Chinese medicine syndrome score were compared between the two groups. Levels of serum nerve cell factors and inflammatory factors were detected. Results： The total effective rate was 95.0% in the observation group and 75.0% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of each Chinese medicine syndrome score between the two groups(P＞ 0.05). After treatment， each Chinese medicine syndrome score in the two groups was decreased when compared with that before treatment， and each score in the observation group was lower than that in the control group， differences being significant(P＜0.05). Before treatment，when compared levels of intercellular adhesion molecule-1(ICAM-1)，insulinlike growth factor- 1(IGF- 1)， vascular endothelial growth factor(VEGF) ， high- sensitivity C- reactive protein(hs- CRP) ， interleukin-6(IL-6)，and tumor necrosis factor-α(TNF-α) in serum between the two groups，there was no significance in the difference(P＞0.05). After treatment， levels of ICAM- 1， hs- CRP， IL- 6， and TNF- α in serum in the two groups were decreased when compared with those before treatment，and the four levels in the observation group were lower than those in the control group(P＜0.05)； levels of IGF- 1 and VEGF in serum were increased when compared with those before treatment， and the two levels in the observation group were higher than those in the control group(P＜0.05). Before treatment，when compared scores of NIHSS，mRS，and FMA between the two groups，there was no significance in the difference(P＞0.05). After treatment， scores of NIHSS and mRS in the two groups were decreased when compared with those before treatment，and the scores of FMA were increased(P＜0.05). After treatment，scores of NIHSS and mRS in the observation group were lower than those in the control group， and the score of FMA was higher(P＜0.05). Conclusion： Qufeng Tongluo prescription in assisted treatment of acute cerebral infarction of wind-phlegm obstructing the collaterals type can effectively improve clinical symptoms， regulate levels of nerve cell factors and inflammatory factors in serum， and improve nerve function and motor function.