Abstract： Objective： To observe the clinical effect of the application of Waizuiba ointment at Yifeng point on treating acute idiopathic facial palsy. Methods： A total of 98 patients with idiopathic facial palsy were selected and divided into the control group and the observation group according to random number table，49 cases in each group. The control group was given conventional western medicine treatment， and the observation group was additionally given Waizuiba ointment at Yifeng point based on the treatment of the control group. The clinical effect，grading of House-Brackmann(H-B) facial nerve function， score of Facial Disability Index(FDI)， vascular endothelial progenitor cells(EPCs) before and after treatment were compared between the two groups. The length and cost of hospital stay，rate of electromyography(EMG) back to normal and adverse reactions were counted. Results：The total effective rate was 79.59% in the observation group，higher than that of 53.06% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference in H-B grading between the two groups(P＞0.05). After treatment，the rate of Ⅰto Ⅱ in the two groups was increased when compared with that before treatment，and the above rate in the observation group was higher than that in the control group， differences being significant(P＜0.05). Before treatment， there was no significant difference in the PDI of physical function(FDIP) and the FDI of social function(FDIS) scores between the two groups(P＞0.05). After treatment，FDIP and FDIS scores in the two groups were increased when compared with those before treatment，and those in the observation group were higher than those in the control group(P＜0.05). Before treatment，there was no significant difference in EPCs count and EPCs colony count between the two groups(P＞0.05). After treatment， the EPCs count and EPCs colony count in the two groups were increased when compared with those before treatment，and the above indexes in the observation group were higher than those in the control group(P＜0.05). The rate of EMG back to normal in the observation group was 71.43%，higher than that of 42.86% in the control group，the difference being significant(P＜0.05). The length and cost of hospital stay in the observation group were shorter or smaller than those in the control group， differences being significant(P＜0.05). The incidence of adverse reactions in the observation group was 10.20%，lower than that of 28.57% in the control group，the difference being significant(P＜0.05). Conclusion： The application of Waizuiba ointment at Yifeng point combined with western medicine for patients with acute idiopathic facial palsy， can better improve the symptoms of facial paralysis， improve muscle function，increase the ability of vascular intima to repair，and shorten the length of hospital stay.