Abstract：Objective：To observe the clinical effect of Wenzhong Xiaoyang tang combined with routine western medicine for gastric ulcer of spleen- stomach deficiency cold type. Methods： A total of 120 cases of patients with gastric ulcer of spleen-stomach deficiency cold type were selected and divided into the control group and the observation group according to the random number table method，60 cases in each group. Patients with helicobacter pylori(Hp) positive in the two groups were given two-week standard quadruple therapy for Hp eradication. The control group was given standard triple therapy of western medicine，and the observation group was additionally treated with Wenzhong Xiaoyang tang based on the treatment of the control group. The clinical effect，the recurrence rate，Chinese medicine syndrome scores，nuclear factor-κB(NF-κB)， and tumor necrosis factor-α(TNF-α) were compared between the two groups. Results：The total effective rate was 95.00% in the observation group， higher than that of 83.33% in the control group(P＜0.05). After treatment for six and twelve months，the recurrence rate in the observation group was lower than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of Chinese medicine syndrome scores between the two groups(P＞0.05). After treatment， Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment， and the scores in the observation group were lower than those in the control group， differences being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of TNF-α and NF-κB in serum between the two groups(P＞0.05). After treatment，levels of TNF-α and NF-κB in serum in the two groups were decreased when compared with those before treatment，and the two levels in the observation group were lower than those in the control group，differences being significant(P＜0.05). Conclusion：In the treatment of gastric ulcer of spleen-stomach deficiency cold type，the therapy of Wenzhong Xiaoyang tang combined with routine western medicine can effectively improve clinical effect，relieve symptoms，enhance antibacterial and anti- inflammatory effect，and reduce the recurrence rate.