Abstract： Objective： To observe the clinical application value of contrast- enhanced ultrasound combined with Tonglin Paishi tang for ureteral calculus. Methods： A total of 179 cases of suspected patients with ucalculus were selected as the research objects， and their related data of clinical diagnosis and treatment was given a retrospective analysis. All patients received clinical contrast- enhanced ultrasound diagnoses， and the 150 case of diagnosed patients were treated with percutaneous nephrolithotomy under the guidance of contrast-enhanced ultrasound. The patients who received operative treatment were divided into the study group and the control group according to their different postoperative treatment，with 75 cases in each group. After operation，the control group was simply treated with routine treatment for residual calculi，and the study group was additionally treated with Tonglin Paishi tang based on the treatment of the control group. The effect of diagnoses and treatment of contrast- enhanced ultrasound on patients were analyzed， and the clinical effect in the two groups was compared. Results： The arrival time(AT) and the time to peak(TTP) of contrast agent at kidney cortex in the ureteral calculus group were shorter than those in the non-ureteral calculus group(P＜0.05)，and the pulsatility index(PI) was higher(P＜0.05). After treatment，the total effective rate was 89.33% in the study group，higher than that of 74.67% in the control group(P＜0.05). After treatment， the Chinese medicine syndrome scores in the two groups were reduced when compared with those before treatment(P＜0.05)， and the levels of serum creatinine(SCr)， blood urea nitrogen(BUN)， interleukin- 6(IL- 6) and tumor necrosis factor- α(TNF- α) were decreased(P＜0.05). After treatment，the Chinese medicine syndrome score in the study group was fewer than that in the control group，and the levels of SCr，BUN，IL-6 and TNF-α in the study group were lower(P＜0.05). The incidence of adverse reactions was 8.00% in the study group，significantly lower than that of 17.33% in the control group(P＜0.05). Conclusion：Contrast-enhanced ultrasound combined with Tonglin Paishi tang can effectively enhance the clinical diagnosis effect of patients，improve the operative curative effect，and promote the discharge of residual calculi，which plays a significant role in improving the body injury and prognosis recovery of patients.