Abstract：Objective：To observe the effect of Bushen Zhuanggu tang combined with western medicine on bone mineral density(BMD) and sex hormones of patients with postmenopausal osteoporosis(PMOP) of liver- kidney yin deficiency type. Methods：A total of 80 PMOP patients were selected and divided into the treatment group and the control group by random number table，40 cases in each group. The control group was treated with alfacalciol tablets and alendronate sodium tablets， and the treatment group was additionally treated with Bushen Zhuanggu tang based on the treatment of the control group. The two groups were treated with one month as a course of treatment for three consecutive courses. The clinical effects in the two groups were observed，the changes of Chinese medicine syndrome score，BMD and levels of sex hormones including serum estradiol(E2) and follicle stimulating hormone(FSH) before and after treatment were compared between the two groups. Results：After treatment，the total effective rate was 92.50% in the treatment group and 75.00% in the control group，the difference being significant(P＜0.05). After treatment， the Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜0.05)， and the Chinese medicine syndrome score in the treatment group was lower than that in the control group(P＜0.05). After treatment， the BMD in the two groups was increased(P＜0.05)，and the BMD in the treatment group was higher than that in the control group(P＜0.05). After treatment， the level of serum E2 in both groups was respectively increased when compared with that before treatment，and the level of serum FSH was decreased；the level of serum E2 in the treatment group was higher than that in the control group，and the level of serum FSH was lower， differences being significant(P＜0.05). Conclusion： The therapy of Bushen Zhuangu tang combined with alfacalciol and alendronate sodium is effective in treating PMOP， which can improve clinical symptoms， regulate the level of sex hormones and increase BMD.