Abstract：Objective：To observe the clinical effect of Xiao'er Feike granules combined with ambroxol hydrochloride and clenbuterol hydrochloride oral solution for acute children bronchiolitis. Methods：A total of 116 cases of children with acute bronchiolitis were divided into the control group and the treatment group according to the random number table method， 58 cases in each group. The control group was treated with ambroxol hydrochloride and clenbuterol hydrochloride oral solution，and the treatment group was additionally treated with Xiao'er Feike granules based on the treatment of the control group. Serum inflammatory factors and indexes of the lung function[Forced inspiratory volume in the first second(FEV1)， forced vital capacity(FVC)，peak expiratory flow(PEF)] before and after treatment，as well as total curative effects，symptom disappearance time and incidence of adverse reactions after treatment were compared between the two groups. Results： After treatment，hs-CRP，TNF-α，IL-6 and IL-18 in the two groups were decreased when compared with those before treatment(P＜0.05)，and the four indexes above in the treatment group were lower than those in the control group(P＜0.05). After treatment，levels of FEV1/FVC and PEF in the two groups were increased when compared with those before treatment (P＜0.05)， and the above two levels in the treatment group were higher than those in the control group(P＜0.05). After treatment，the recovery time of temperature，as well as the disappearance time of cough and lung rales in the treatment group were earlier than those in the control group，differences being significant(P＜0.05). After treatment，the total effective rate was 93.10% in the treatment group and 70.69% in the control group， the difference being significant(P＜0.05). After two- week treatment， the incidence of adverse reactions was 10.34% in the treatment group and 27.59% in the control group，the difference being significant(P＜0.05). Conclusion：Xiao'er Feike granules combined with ambroxol hydrochloride and clenbuterol hydrochloride oral solution in the treatment of acute children bronchiolitis can relieve clinical effects，improve respiratory inflammatory responses and the lung function，and shorten the course of the disease.