金龙胶囊联合XELOX 化疗方案对胃癌患者生活质量及细胞免疫功能的影响
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R735.2

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Effect of Jinlong Capsules Combined with XELOX Chemotherapy Regimen on Quality of Life and Cellular Immune Function in Patients with Gastric Cancer
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    摘要:

    目的:观察金龙胶囊联合XELOX 化疗方案治疗胃癌的临床疗效及对患者生活质量、细胞免疫功能的影响。方法:选取93 例胃癌患者,按随机数字表法分为对照组46 例、联合组47 例。对照组采用XELOX 化疗方案,观察组在对照组基础上加用金龙胶囊。2 组疗程均为2~4 个化疗周期。比较2 组临床疗效,观察2 组治疗前后Karnofsky 评分(KPS 评分) 及细胞免疫功能(T 淋巴细胞亚群CD3+、CD4+、CD4+/CD8+) 变化、不良反应发生率。结果:治疗后,联合组总有效率为59.57%,对照组总有效率为39.13%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组KPS 评分均较治疗前上升,联合组KPS 评分高于对照组,差异均有统计学意义(P<0.05)。治疗后,联合组CD3+、CD4+、CD4+/CD8+指标值均较治疗前上升(P<0.05),对照组上述3 项指标值均较治疗前下降(P<0.05),联合组上述3 项指标值均高于对照组,差异均有统计学意义(P<0.05)。1 个化疗周期后,联合组胃肠道反应、白细胞减少、血小板减少、脱发及贫血发生率均低于对照组,差异均有统计学意义(P<0.05)。结论:金龙胶囊联合XELOX 化疗方案治疗胃癌的临床疗效优于单一XELOX 方案化疗,可改善患者生活质量,增强免疫功能,用药安全性较高。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Jinlong capsules combined with XELOX chemotherapy regimen for gastric cancer and its effect on the quality of life and cellular immune function. Methods:A total of 93 cases of patients with gastric cancer were selected and divided into the control group and the combination group according to the random number table method, 46 and 47 cases in each group respectively. The control group was treated with XELOX chemotherapy regimen, and the observation group was additionally treated with Jinlong capsules based on the treatment of the control group. Both groups were treated for two to four chemotherapy cycles. The clinical effects in the two groups were compared; the changes of Karnofsky scores(KPS scores) and cellular immune function including T lymphocyte subsets CD3+,CD4+ and CD4 +/CD8 + as well as the incidences of adverse reactions were observed before and after treatment. Results: After treatment, the total effective rate was 59.57% in the combination group and 39.13% in the control group, the difference being significant(P<0.05). After treatment,KPS scores in the two groups were increased when compared with those before treatment,and the score in the combination group was higher than that in the control group,differences being significant(P< 0.05). After treatment,the indexes of CD3+,CD4+ and CD4+/CD8+ in the combination group were increased when compared with those before treatment(P<0.05),and the above indexes in the control group were decreased(P<0.05);the above three indexes in the combination group were higher than those in the control group,differences being significant(P<0.05). After treatment, the incidences of gastrointestinal reactions, leukopenia, thrombocytopenia, alopecia and anemia in the combination group were lower than those in the control group, the difference being significant(P<0.05). Conclusion: The therapy of Jinlong capsules combined with XELOX chemotherapy regimen for gastric cancer has a higher clinical effect than simple XELOX chemotherapy,which can improve the quality of life of patients and enhance the immune function with higher medication safety.

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温敏雅,盛倩,章国东.金龙胶囊联合XELOX 化疗方案对胃癌患者生活质量及细胞免疫功能的影响[J].新中医,2021,53(19):152-155

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  • 在线发布日期: 2021-10-09
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