Abstract： Objective： To observe the clinical effect of butylphthalide and sodium chloride injection combined with warming- needle moxibustion for progressive stroke(PS). Methods：A total of 80 cases of PS patients of qi deficiency with blood stasis type were divided into the study group and the control group according to the random number table method， 40 cases in each group. The control group was treated with butylphthalide and sodium chloride， and the study group was additionally treated with warming-needle moxibustion based on the treatment of the control group. Both groups were treated for 28 days. Triglyceride(TG)，homocysteine(Hcy)，angiotensin Ⅱ(ANGⅡ) and the scores of Stroke- Specific Quality of Life Scale(SS-QOL) before and after treatment as well as the adverse reactions in the two groups were compared. Results：After treatment，the levels of TG，ANG Ⅱ and Hcy in the two groups were decreased when compared with those before treatment (P＜0.05)，and the scores of each dimension in SS-QOL and the total scores were increased(P＜0.05). After treatment，the levels of TG，ANG Ⅱ and Hcy in the study group were lower than those in the control group(P＜0.05)，and the score of each dimension in SS-QOL and the total score were higher(P＜0.05). During treatment，there was no significant difference being found in the comparison of the total incidences of adverse reactions between the two groups(P＞0.05). Conclusion： The therapy of butylphthalide and sodium chloride injection combined with warming- needle moxibustion for PS can effectively reduce the risk of cerebral circulation dysfunction and improve the quality of life of patients，with high safety.