Abstract： Objective： To observe the clinical effect of thunder- fire moxibustion at Shenque point for patients with insomnia after cerebral infarction. Methods：A total of 80 cases of patients with insomnia after cerebral infarction were divided into the control group and the observation group according to the random number table method，40 cases in each group. Both groups were given routine basic treatment of western medicine；the control group was additionally treated with estazolam tablets， and the observation group was additionally treated with thunder- fire moxibustion at Shenque point. The clinical effect，the scores of Pittsburgh Sleep Quality Index(PSQI)，the changes in Chinese medicine syndrome scores and the levels of 5- hydroxyserotonin(5- HT)， brain- derived neurotrophic factor(BDNF) and Orexin- A in serum in the two groups were compared； the incidences of adverse reactions were observed. Results： The total effective rate was 92.50% in the observation group， higher than that of 75.00% in the control group， the difference being significant(P＜0.05). After treatment， the scores of PSQI and the total scores in the two groups were decreased when compared with those before treatment， and the above scores in the observation group were lower than those in the control group(P＜0.05). After treatment， Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment，and the score in the observation group was lower than that in the control group，differences being significant(P＜ 0.05). After treatment，the levels of 5- HT and BDNF in the two groups were increased when compared with those before treatment，and the levels in the observation group were higher than those in the control group(P＜0.05)；the levels of Orexin- A in the two groups were decreased when compared with those before treatment，and the level in the observation group was lower than that in the control group(P＜0.05). The incidence of adverse reactions was 5.00% in the observation group，lower than that of 20.00% in the control group，the difference being significant(P＜0.05). Conclusion：The application of thunderfire moxibustion at Shenque point for insomnia after cerebral infarction has significant effect，and can significantly improve the insomnia of patients，increase the levels of 5-HT and BDNF，and reduce the levels of orexin-A.