Abstract： Objective： To observe the clinical effect of moxibustion combined with moist exposed burn ointment for pressure injury. Methods：A total of 84 cases of patients with pressure injury were selected and divided into the control group and the treatment group according to random number table method，42 cases in each group. Based on the same nursing， the control group was treated with moist exposed burn ointment，and the treatment group was given moist exposed burn ointment after moxibustion. The knowledge level of pressure injury， score of Self- Rating Anxiety Scale(SAS) and Self- Rating Depression Scale(SDS)， recovery time of pH value of granulation tissue and healing time of pressure injury were observed before and after nursing in the two groups. The nursing satisfaction and clinical effect were compared between the two groups. Results： After nursing， scores of knowledge of pressure injury in the two groups were increased when compared with those before nursing(P＜0.05)，and the score in the treatment group was higher than that in the control group (P＜0.05). After nursing，scores of SAS and SDS in the two groups were decreased when compared with those before nursing (P＜0.05)，and the two scores in the treatment group were lower than those in the control group(P＜0.05). The recovery time of pH value of granulation tissue in the treatment group was shorter than that in the control group， the difference being significant(P＜0.05). After nursing， the time of wound healing in the treatment group was shorter than that in the control group， and there was significant difference being found in the comparison of the time for 40% ， 60% ， 80% and 100% healing(P＜0.05). The nursing satisfaction rate was 97.62% in the treatment group，higher than that of 71.43% in the control group，the difference being significant(P＜0.05). The total effective rate was 73.81% in the control group，and 92.86% in the treatment group， the difference being significant(P＜0.05). Conclusion： The therapy of moxibustion combined with moist exposed burn ointment for pressure injury can relieve anxiety，depression，and stress，promote the recovery of granulation tissue，and improve nursing satisfaction.