Abstract： Objectives： To observe the curative effect of Modified Linggui Zhugan tang on chronic heart failure and its effect on the contents of N-terminal pro-B-type natriuretic peptide(NT-proBNP) and soluble growth stimulation expressed gene 2(sST2) in serum. Methods： A total of 74 cases of patients with chronic heart failure were randomly divided into the study group and the control group，with 37 cases in each group. The control group was treated with routine treatment for chronic heart failure such as antihypertensive， lipid- lowering and anticoagulation treatment， and the study group was additionally treated with modified Linggui Zhugan tang based on the treatment of the control group. The two groups were continuously treated for four weeks. After treatment，the clinical effect in the two groups was analyzed and compared，and the Chinese medicine syndrome scores in the two groups before and after treatment were compared. Before and after treatment， the levels of left ventricular ejection fraction(LVEF)， left ventricular end- diastolic diameter(LVEDd) and left ventricular end-systolic diameter(LVESd) and the levels of NT-proBNP and sST2 in serum in the two groups were detected. During treatment， vital signs such as respiration， heart rate and blood pressure were monitored， and the incidences of adverse reactions were recorded. Results：After treatment，the clinical effect in the study group was better than that in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of Chinese medicine syndrome scores between the two groups(P＞0.05). After treatment，Chinese medicine syndrome scores in the two groups were lower than those before treatment(P＜0.05)，and the score in the study group was lower than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the levels of LVEF， LVEDd， and LVESd between the two groups(P＞0.05). After treatment， the levels of LVEF in the two groups were increased when compared with those before treatment(P＜0.05)， the levels of LVEDd and LVESd were decreased(P＜0.05)，and the improvement of the above levels in the study group was more significant than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the contents of NT-proBNP and sST2 in serum between the two groups(P＞0.05). After treatment，the contents of NT-proBNP and sST2 in serum in the two groups were decreased when compared with those before treatment(P＜0.05)， and the contents of NT-proBNP and sST2 in the study group were lower than those in the control group(P＜0.05). During treatment， there were no obvious abnormality in respiratory，heart rate and blood pressure in the two groups，and no obvious adverse reactions. Conclusion：Modified Linggui Zhugan tang for patients with chronic heart failure has definite curative effect，which can effectively alleviate clinical symptoms， reduce levels of sST2 and NT- proBNP in serum， and improve heart function， with good safety.