Abstract： Objective： To observe the effect of the therapy of Chinese medicine rehabilitation combined with physical rehabilitation training on the activity of daily living and mental status of senile patients with mental illness. Methods：A total of 87 senile patients with mental illness were selected and divided into the control group and the observation group according to random number table，43 and 44 cases in each group. The control group was intervened with physical rehabilitation training， and the observation group was given Chinese medicine rehabilitation based on the treatment of the control group. The lung function， exercise endurance and the incidence of falls， mental status， activity of daily living and quality of life were observed and compared between the two groups before and after intervention. Results：Before intervention，there was no significant difference in forced vital capacity(FVC)， forced expiratory volume in the first second(FEV1)， 6- minute walking distance(6MWD) and peak ventilation ratio between the two groups(P＞0.05). After intervention，the levels of FVC，FEV1， 6MWD and peak ventilation ratio in the observation group were increased when compared with those before intervention(P＜ 0.05)，and the above levels in the observation group were higher than those in the control group(P＜0.05). During treatment， the incidence of falls was 9.09% in the observation group and 41.86% in the control group，the difference being significant (P＜0.05). Before intervention，there was no significant difference in the scores of Mini- Mental State Examination(MMSE) and Brief Psychiatric Rating Scale(BPRS) between the two groups(P＞0.05). After intervention，scores of MMSE and BPRS in both groups were decreased when compared with those before treatment(P＜0.05)，and the two scores in the observation group were lower than those in the control group(P＜0.05). Before intervention， there was no significant difference in the environmental factors，social relations，physiological and psychological scores in World Health Organization Quality of Life- BREF(WHOQOL-BREF) and the scores of Activity of Daily Living(ADL) between the two groups(P＞0.05). After intervention， the scores of all indicators in the WHOQOL- BREF and ADL in the two groups were increased when compared with those before treatment(P＜0.05)， and the scores of the above indicators in the observation group were higher than those in the control group(P＜0.05). Conclusion： The therapy of Chinese medicine rehabilitation combined with physical rehabilitation training can effectively enhance the lung function and exercise endurance，improve the mental state and ability of daily living and quality of life，and reduce the incidence of falls in elderly patients with mental illness.