Abstract：Objective：To observe the improvement effect of Chinese medicine diet combined with compound α-ketoacid tablets based on routine therapy on nutritional status of patients with maintenance hemodialysis with spleen- kidney yang deficiency syndrome. Methods：A total of 88 cases of patients were divided into the control group and the observation group， 44 cases in each group. Both groups were given routine therapy and treated with compound α- ketoacid tablets ， and the observation group was intervened with Chinese medicine diet Shenxian porridge. Both groups were treated for eight weeks. One day before treatment and after eight-week treatment respectively，the levels of growth hormone(GH)，albumin (Alb)， prealbumin(PA) and transferrin(TRF) in serum ， the nutritional status[Modified Quantitative Subjective Global Assessment(MQSGA) score]，and the symptom scores of spleen-kidney yang deficiency syndrome in the two groups were compared. Results： After eight- week treatment， the levels of GH， Alb， PA and TRF in serum in the two groups were increased when compared with those on one day before treatment(P＜0.01)， and the levels of GH， Alb， PA and TRF in serum in the observation group were higher than those in the control group(P＜0.01). The MQSGA scores in the two groups were decreased when compared with those on one day before treatment(P＜0.01)，and the MQSGA score in the observation group was lower than that in the control group(P＜0.01). The scores of chilliness and cold limbs，soreness and weakness of waist and knees，loose stool，pale complexion，long-lasting night-uria in the two groups were decreased when compared with those on one day before treatment(P＜0.01)，and the above five symptom scores in the observation group were lower than those in the control group(P＜0.01). Conclusion： Based on routine therapy， the additional intervention of Chinese medicine diet combined with compound α- ketoacid tablets can significantly improve the nutritional status and Chinese medicine syndromes of patients with maintenance hemodialysis with spleen-kidney yang deficiency syndrome.