Abstract：Objective：To observe the clinical effect of modified Zhimi Fuling pills combined with Huangqi Guizhi Wuwu tang for diabetic peripheral neuropathy(DPN) with phlegm stasis obstructing the collaterals syndrome. Methods： A total of 86 cases of DPN patients with phlegm stasis obstructing the collaterals syndrome were divided into the control group and the observation group according to the random number table method， with 43 cases in each group. Both groups were given routine treatment measures based on the guideline；the control group was given oral administration of mecobalamin tablets， and the observation group was additionally treated with modified Zhimi Fuling pills combined with Huangqi Guizhi Wuwu tang based on the treatment of the control group. Both groups were treated for four weeks. Before and after treatment， the changes in lower extremities vibration perception thresholds，and the scores of Toronto Clinical Scoring System(TCSS) and Chinese medicine syndromes in the two groups were compared. The clinical effects in the two groups were evaluated. Results：The total effective rate was 76.74% in the observation group，significantly higher than that of 53.49% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of lower extremities vibration perception thresholds between the two groups(P＞0.05). After treatment， the lower extremities vibration perception thresholds in the two groups were decreased when compared with those before treatment(P＜0.05)，and the one in the observation group was significantly lower than that in the control group，differences being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the scores of TCSS and Chinese medicine syndromes between the two groups(P＞0.05). After treatment， the scores of TCSS and Chinese medicine syndromes were decreased when compared with those before treatment， and the scores in the observation group were lower than those in the control group，differences being significant(P＜0.05). Conclusion：Based on routine treatment of western medicine，the additional application of modified Zhimi Fuling pills combined with Huangqi Guizhi Wuwu tang for DPN with phlegm stasis obstructing the collaterals syndrome can further improve the clinical symptoms of patients with better curative effect.