参芪地黄汤联合阿法骨化醇软胶囊对糖尿病肾病患者炎性因子、微量白蛋白及激素水平的影响
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R587.2

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河南省教育厅高等学校重点科研项目(18B310011)


Effect of Shenqi Dihuang Tang Combined with Alfacalcidol Soft Capsules on Levels of Inflammatory Factors, Microalbumin and Hormones in Patients with Diabetic Nephropathy
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    摘要:

    目的:观察参芪地黄汤联合阿法骨化醇软胶囊对糖尿病肾病患者炎性因子、尿微量白蛋白(mAlb) 及激素水平的影响。方法:选取144 例糖尿病肾病患者,按随机数字表法分为对照组及观察组各72 例。对照组在常规治疗基础上口服阿法骨化醇软胶囊,观察组在对照组基础上加用参芪地黄汤。观察2 组临床疗效,比较2 组治疗前后炎性因子[肿瘤坏死因子-α(TNF-α)、血清超敏C-反应蛋白(hs-CRP)] 水平、肾功能[尿氮素(BUN)、血肌酐(SCr)]、mAlb、尿白蛋白排泄率(UAER)、激素[空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)] 水平,比较2 组治疗前后中医证候积分,观察治疗期间2 组不良反应发生情况。结果:治疗后,2 组TNF-α、hs-CRP 水平均较治疗前下降,观察组上述2 项水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2 组BUN、SCr 水平均较治疗前下降,观察组上述2 项水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2 组mAlb、UAER 水平均较治疗前下降,观察组上述2 项水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2 组FINS、HOMA-IR 水平均较治疗前下降,观察组上述2 项水平均低于对照组,差异均有统计学意义(P<0.05)。观察组临床疗效总有效率为94.44%,对照组总有效率为83.33%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组中医证候积分中主症积分、次症积分均较治疗前下降,观察组主症积分、次症积分均低于对照组,差异均有统计学意义(P<0.05)。对照组不良反应发生率为8.33%,高于观察组4.17%,差异无统计学意义(P>0.05)。结论:参芪地黄汤联合阿法骨化醇软胶囊治疗糖尿病肾病临床疗效较好,能控制炎性因子和激素水平,改善肾功能,用药安全性较高。

    Abstract:

    Abstract:Objectives:To observe the effect of Shenqi Dihuang tang combined with alfacalcidol soft capsules on levels of inflammatory factors,urinary microalbumin(mAlb) and hormones in patients with diabetic nephropathy. Methods:A total of 144 cases of patients with diabetic nephropathy were divided into the control group and the observation group according to the random number table method, with 72 cases in each group. The control group was treated with the oral administration of alfacalcidol soft capsule based on the conventional treatment,and the observation group was additionally treated with Shenqi Dihuang tang based on the treatment of the control group. The clinical effects in the two groups were observed. Before and after treatment, the levels of inflammatory factors [tumor necrosis factor- α(TNF- α), serum high- sensitivity C- reactive protein(hs- CRP)], renal function [urinary nitrogen(BUN), serum creatinine(SCr)], mAlb, urinary albumin excretion rate (UAER), hormones [fasting insulin(FINS), Homeostatic Model Assessment- Insulin Resistance(HOMA- IR)], and Chinese medicine syndrome scores in the two groups were compared. During treatment,the incidence of adverse reactions in the two groups was observed. Results:After treatment,the levels of TNF- α and hs- CRP in the two groups were decreased when compared with those before treatment,and the above two levels in the observation group were lower than those in the control group, differences being significant(P<0.05). After treatment, levels of BUN and SCr in the two groups were decreased when compared with those before treatment,and the two levels in the observation group were lower than those in the control group, differences being significant(P<0.05). After treatment, levels of mAlb and UAER in the two groups were decreased when compared with those before treatment,and the two levels in the observation group were lower than those in the control group,differences being significant(P<0.05). After treatment,levels of FINS and HOMA-IR in the two groups were decreased when compared with those before treatment,and the two levels in the observation group were lower than those in the control group,differences being significant(P<0.05). The total effective rate was 94.44% in the observation group, and was 83.33% in the control group, the difference being significant(P<0.05). After treatment, the main and secondary symptom scores of Chinese medicine symptom scores in the two groups were decreased when compared with those before treatment, and the above two scores in the observation group were lower than those in the control group, differences being significant(P<0.05). The incidence of adverse reactions was 8.33% in the control group,higher than that of 4.17% in the observation group, there being no significance in the difference(P>0.05). Conclusion: Shenqi Dihuang tang combined with alfacalcidol soft capsules for diabetic nephropathy has a good clinical effect,which can control the levels of inflammatory factors and hormones in patients,and improve their kidney function,with a high safety.

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常红叶,徐利萍,程团结,陈小平,齐昆青,徐璐璐,尚祥岭.参芪地黄汤联合阿法骨化醇软胶囊对糖尿病肾病患者炎性因子、微量白蛋白及激素水平的影响[J].新中医,2021,53(21):43-48

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  • 在线发布日期: 2021-11-12
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