Abstract：Objective：To observe the effect of Lixin pills combined with valsartan on the treatment of chronic heart failure and its effect on Minnesota Living with Heart Failure Questionnaire(MLHFQ) score and 6 Min Walking Test(6MWT). Methods： The clinical data of 85 patients with chronic heart failure were analyzed retrospectively，and they were divided into the control group and the observation group according to different treatment methods. A total of 43 cases in the control group were given valsartan capsules orally，and 42 cases in the observation group were given Lixin pills based on the treatment in the control group. The clinical effect in the two groups was compared ， and the levels of cardiac function indexes ， MLHFQ score， 6MWT and serum inflammatory factors were compared between the two groups before and after treatment. Results： Compared with those in the same group before treatment， the left ventricular end- diastolic diameter(LVEDD)， left ventricular end- systolic diameter(LVESD)， MLHFQ score and the levels of serum interleukin- 6(IL- 6)， tumor necrosis factor- α(TNF- α) and hypersensitive C- reactive protein(hs- CRP) in both groups were decreased after treatment(P＜0.05)， and the left ventricular ejection fraction(LVEF) and 6MWT were increased(P＜0.05). Compared with those in the control group，LVEDD，LVESD，MLHFQ scores and levels of serum IL-6，hs-CRP and TNF-α were lower in the observation group after treatment(P＜0.05)， while LVEF and 6MWT were higher(P＜0.05). The total effective rate was 92.85% in the observation group，higher than that of 76.74% in the control group(P＜0.05). Conclusion：The therapy of Lixin pills combined with valsartan for chronic heart failure can effectively improve clinical effect， improve the heart function， reduce levels of serum inflammatory factor，increase 6MWT，and reduce MLHFQ score.