脑栓通胶囊联合丁苯酞治疗脑梗死临床研究
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R743.33

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Clinical Study on Naoshuantong Capsules Combined with Butylphthalide for Cerebral Infarction
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    摘要:

    目的:观察脑栓通胶囊联合丁苯酞治疗脑梗死的临床疗效及安全性。方法:选取120 例脑梗死患者,按随机数字法随机分为观察组与对照组,各60 例。对照组采用丁苯酞治疗,观察组在对照组基础上服用脑栓通胶囊治疗。比较2 组治疗前后基质金属蛋白酶-8(MMP-8)、S100β 蛋白表达水平及美国国立卫生研究院卒中量表(NIHSS) 评分,并比较2 组临床疗效及不良反应。结果:与同组治疗前比较,治疗后2 组MMP-8、S100β 蛋白表达水平及NIHSS 评分均降低(P<0.05);与对照组治疗后比较,观察组治疗后MMP-8、S100β 蛋白表达水平及NIHSS 评分均较低(P<0.05)。治疗后,观察组总有效率为93.33%,高于对照组78.33%(P<0.05)。治疗后,2 组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:脑栓通胶囊联合丁苯酞治疗脑梗死疗效显著,且安全性较高。

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    Abstract:Objective:To observe the clinical effect and safety of Naoshuantong capsules combined with butylphthalide in the treatment of cerebral infarction. Methods: A total of 120 cases of patients with cerebral infarction were selected and divided into the observation group and the control group according to the random number table method, 60 cases in each group. The control group was treated with butylphthalide, and the observation group was additionally treated with Naoshuantong capsules based on the treatment of the control group. Before and after treatment, levels of matrix metalloproteinase-8(MMP-8) and the expression of S100 β protein , scores of National Institutes of Health Stroke Scale (NIHSS),clinical effects and adverse reactions were compared between the two groups. Results:After treatment,levels of MMP-8 and S100β protein expression as well as NIHSS scores in the two groups were decreased when compared with those before treatment(P<0.05). After treatment,levels of MMP- 8 and S100β protein expression as well as NIHSS score in the observation group were lower than those in the control group(P<0.05). After treatment,the total effective rate was 93.33% in the observation group,higher than that of 78.33% in the control group(P<0.05). After treatment,there was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P>0.05). Conclusion: The therapy of Naoshuantong capsules combined with butylphthalide has a significant curative effect in the treatment of cerebral infarction,with high safety after treatment.

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武晓波.脑栓通胶囊联合丁苯酞治疗脑梗死临床研究[J].新中医,2021,53(21):84-87

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  • 在线发布日期: 2021-11-12
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