Abstract：Objective：To observe the clinical effect and safety of Naoshuantong capsules combined with butylphthalide in the treatment of cerebral infarction. Methods： A total of 120 cases of patients with cerebral infarction were selected and divided into the observation group and the control group according to the random number table method， 60 cases in each group. The control group was treated with butylphthalide， and the observation group was additionally treated with Naoshuantong capsules based on the treatment of the control group. Before and after treatment， levels of matrix metalloproteinase-8(MMP-8) and the expression of S100 β protein ， scores of National Institutes of Health Stroke Scale (NIHSS)，clinical effects and adverse reactions were compared between the two groups. Results：After treatment，levels of MMP-8 and S100β protein expression as well as NIHSS scores in the two groups were decreased when compared with those before treatment(P＜0.05). After treatment，levels of MMP- 8 and S100β protein expression as well as NIHSS score in the observation group were lower than those in the control group(P＜0.05). After treatment，the total effective rate was 93.33% in the observation group，higher than that of 78.33% in the control group(P＜0.05). After treatment，there was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P＞0.05). Conclusion： The therapy of Naoshuantong capsules combined with butylphthalide has a significant curative effect in the treatment of cerebral infarction，with high safety after treatment.