Abstract：Objective：To observe the effect of Fuzheng Huayu capsules combined with entecavir dispersible tablets on liver function and T lymphocyte subsets in patients with liver fibrosis due to chronic hepatitis B(CHB). Methods： A total of 202 cases of CHB patients with liver fibrosis were given a retrospective analysis of their clinical data， and divided into the control group and the observation group according to their treatment methods，101 cases in each group. The control group was treated with entecavir dispersible tablets， and the observation group was additionally treated with Fuzheng Huayu capsules based on the treatment of the control group. Both groups were treated for one month. Before and after treatment， the changes of the indexes of liver function including alanine aminotransferase(ALT)， aspartate aminotransferase(AST) and total bilirubin(TBil)，as well as the levels of T lymphocyte subsets including CD3 +，CD4 + and CD4 +/CD8 + in the two groups were compared. The clinical effects and the incidences of adverse reactions in the two groups were evaluated. Results：The total effective rate was 97.03% in the observation group， higher than that of 88.12% in the control group， the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the liver function indexes between the two groups(P＞0.05). After treatment，the levels of ALT，AST and TBil in the two groups were decreased when compared with those before treatment， and the levels of liver function indexes in the observation group were lower than those in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the levels of T lymphocyte subsets between the two groups(P＞0.05). After treatment，the levels of CD3 +，CD4 + and CD4 +/CD8 + in the two groups were increased when compared with those before treatment，and the above levels in the observation group were higher than those in the control group，the difference being significant(P＜0.05). The incidence of adverse reactions was 2.97% in the observation group and 6.93% in the control group， there being no significance in the difference(χ 2=0.194， P=1.683). Conclusion： Fuzheng Huayu capsules combined with entecavir dispersible tablets has a significant curative effect in treating liver fibrosis due to CHB，which can effectively improve liver function and levels of T lymphocyte subsets，with good safety.