Abstract：Objective：To observe the clinical effect of Shenshuaining tablets combined with piperazine ferulate tablets for diabetic nephropathy and its effect on kidney function and inflammatory factors. Methods：A total of 56 cases of patients with diabetic nephropathy were given a retrospective analysis on their clinical data and were divided into the control group and the observation group according to different treatment methods，with 28 cases in each group. The control group was given oral administration of piperazine ferulate tablets， and the observation group was additionally given oral administration of Shenshuaining tablets based on the treatment of the control group. The clinical effects in the two groups were observed. Before and after treatment，the kidney function and inflammatory factor levels in the two groups were compared. Results： After treatment， the levels of fasting blood glucose(FBG)， 2- hour postprandial plasma glucose(P2hBG)， glycated hemoglobin(HbA1c) ， serum creatinine(SCr) ， microalbuminuria(MAU) ， blood urea nitrogen(BUN) ， 24-hour urine protein (24 hUP) and serum interleukin- 6(IL- 6)， interleukin- 8(IL- 8)， tumor necrosis factor- α(TNF- α) and high- sensitivity Creactive protein(hs-CRP) in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of FBG，P2hBG，HbA1c，SCr，MAU，BUN，24 hUP，as well as serum IL- 6，hs- CRP，TNF- a and IL- 8 in the observation group were lower than those in the control group(P＜0.05). The total effective rate was 89.29% in the observation group， higher than that of 64.29% in the control group(P＜0.05). Conclusion： Shenshuaining tablets combined with piperazine ferulate tablets for diabetic nephropathy can effectively reduce inflammatory responses of patients， regulate plasma glucose and kidney function，and enhance clinical effects.