Abstract：Objective：To observe the clinical effect of Huangqi Guizhi Wuwu tang combined with acupuncture and Tuina for cervical spondylosis with radiculopathy(CSR). Methods：A total of 120 cases of CSR patients were randomly divided into the control group and the experiment group，60 cases in each group. The control group was treated with cattle encephalon glycoside and ignotin injection， and the experiment group was treated with Huangqi Guizhi Wuwu tang combined with acupuncture and Tuina. The clinical effect was observed and compared between the two groups. Changes in Cobb angle， scores of cervical spine function and the Short Form 36 Health Survey(SF- 36)，as well as levels of lipid peroxide(LPO) and interleukin-1β(IL-β) in serum were compared between the two groups before and after treatment. Results：The total clinical effective rate was 96.67% in the experiment group and 73.33% in the control group， the difference being significant(P＜ 0.05). Before treatment， there was no significant difference being found in the comparison of Cobb angles and scores of cervical spine function between the two groups(P＞0.05). After treatment，Cobb angles and scores of cervical spine function in the two groups were increased when compared with those before treatment(P＜0.05)， and the two indexes in the experiment group were both higher than those in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of LPO and IL- 1β in serum between the two groups(P＞0.05). After treatment， levels of LPO and IL- 1β in the two groups were decreased when compared with those before treatment(P＜ 0.05)， and the two indexes in the experiment group were both lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of SF- 36 scores between the two groups(P＞ 0.05). After treatment， SF- 36 scores in the two groups were increased when compared with those before treatment(P＜ 0.05)，and the score in the experiment group was higher than that in the control group(P＜0.05). Conclusion：The therapy of Huangqi Guizhi Wuwu tang combined with acupuncture and Tuina can effectively relieve pain in neck and shoulder of CSR patients，alleviate inflammatory responses，and improve quality of life.