Abstract：Objective：To observe the clinical effect of modified Danzhi Xiaoyao powder combined with propylthiouracil for gestational hyperthyroidism(GHT) of intense liver fire type. Methods：A total of 120 cases of patients with GHT of intense liver fire type were selected and divided into the control group and the observation group according to the random number table method，with 60 cases in each group. The control group was treated with propylthiouracil，and the observation group was treated with modified Danzhi Xiaoyao powder combined with propylthiouracil. The levels of thyroid hormone and glucose and lipid metabolism before and after treatment as well as the pregnancy outcomes in the two groups were compared. Results： The amount of postpartum hemorrhage in the observation group was less than that in the control group(P＜0.05)， and neonatal Apgar score was higher(P＜0.05). The puerperal infection rate was 5.00% in the observation group，lower than that of 18.33% in the control group(P＜0.05)；the vaginal delivery rate was 80.00% in the observation group，higher than that of 58.33% in the control group(P＜0.05). After treatment，the levels of thyroid stimulating hormone(TSH) in the two groups were increased when compared with those before treatment(P＜0.05)，and the TSH level in the observation group was higher than that in the control group(P＜0.05). The levels of free thyroxine(FT4)，free triiodothyronine(FT3)，fasting blood glucose(FBG)， fasting insulin(FINS)，total cholesterol(TC) and triglyceride(TG) in the two groups were decreased when compared with those before treatment(P＜0.05)；the levels of FT4，FT3，FBG，FINS，TC and TG in the observation group were lower than those in the control group(P＜0.05). Conclusion：The therapy of modified Danzhi Xiaoyao powder combined with propylthiouracil for GHT of intense liver fire type can improve the pregnancy outcome and effectively regulate the levels of thyroid hormone and glucose and lipid metabolism.