Abstract： Objective： To observe the clinical effect of Shenmai injection combined with cefoperazone and sulbactam sodium on the treatment of senile severe infection and its effect on the lung function. Methods：A total of 110 elderly patients with severe infection were selected and divided into the control group and the observation group according to random number table method，55 cases in each group. The control group was treated with cefoperazone and sulbactam sodium based on the basis of basic maintenance therapy，and the observation group was treated with Shenmai injection based on the treatment of the control group. The body temperature， white blood cell count， platelet count， procalcitonin(PCT)， C- reactive protein (CRP)， serum albumin(Alb)， forced expiratory volume in the first second(FEV1) and forced vital capacity(FVC) in the two groups were compared before and after treatment. The clinical effect in the two groups were counted. Results：The clinical effect in the observation group was better than that in the control group， the difference being significant(P＜0.05). After treatment，the body temperature and white blood cell count in the two groups were decreased when compared with those before treatment(P＜0.05)，and the platelet count was increased when compared with that before treatment(P＜0.05)；the improvement of the above indexes in the observation group was more significant than that in the control group(P＜0.05). After treatment，the levels of serum PCT and CRP in both groups were decreased when compared with those before treatment(P＜ 0.05)， and the level of Alb was increased compared with that before treatment(P＜0.05)； the improvement of the above indexes in the observation group was more significant than that in the control group(P＜0.05). After treatment，the levels of FEV1 and FVC in both groups were higher than those before treatment(P＜0.05)，and the above two levels in the observation group were higher than those in the control group(P＜0.05). Conclusion： The therapy of Shenmai injection combined with cefoperazone and sulbactam sodium in the treatment of elderly patients with severe infection can better control infection， improve lung function and enhance clinical effect.