Abstract：Objective：To observe the clinical effect of Qingre Lishi Zhidai prescription on leukorrhea of damp-heat pouring downward type. Methods：A total of 97 patients with leukorrhea of damp-heat pouring downward type were selected as the research object，and randomly divided into the experiment group(49 cases) and the control group(48 cases). The experiment group was treated with self- designed Qingre Lishi Zhidai prescription，and the control group was treated with clotrimazole vaginal tablets and metronidazole tablets. The treatment course of both groups was seven days. The clinical effect，symptom improvement，vaginal cleanliness，adverse reactions and recurrence were observed and compared between the two groups. Results：The total effective rate was 97.96% in the experiment group and 87.50% in the control group，the difference being significant(P＜0.05). The disappearance rate of symptoms such as abnormal color，quality and smelling of leucorrhea，bitter mouth and greasy coating，lack of appetite，yellow urine and contact pain in the experiment group was higher than that in the control group， differences being significant(P＜0.05). The classification of vaginal cleanliness in the experiment group was better than that in the control group，the difference being significant(P＜0.05). The rate of adverse reactions was 2.04% in the experiment group and 29.17% in the control group，the difference being significant(P＜0.05). The recurrence rate was 4.08% in the experiment group and 19.05% in the control group，the difference being significant(P＜0.05). Conclusion：Qingre Lishi Zhidai prescription can improve the clinical symptoms and the vaginal cleanliness in patients with leukorrhea of damp- heat pouring downward type，and the recurrence rate is low，with less adverse reactions.