Abstract： Objectives： To observe the clinical effect of Xiaoer Chaigui Tuire granules combined with oseltamivir phosphate for influenza in children. Methods：A total of 100 cases of children with influenza were selected and divided into the observation group and the control group according to the random number table method，with 50 cases in each group. The control group was treated with oseltamivir phosphate capsules， and the observation group was additionally treated with Xiaoer Chaigui Tuire granules based on the treatment of the control group. Both groups were treated for seven days. The clinical effects， incidence of adverse reactions and the regression time of clinical symptoms in the two groups were compared. Before and after treatment，the levels of serum high- sensitivity C- reactive protein(hs- CRP) in the two groups were compared. Results：The total effective rate was 96.00% in the observation group，higher than that of 80.00% in the control group(P＜0.05). The incidence of adverse reactions was 2.00% in the observation group， and was 14.00% in the control group，the difference being significant(P＜0.05). When compared with those in the control group，fever subsidence began and was completed earlier in the observation group，and the time of regression of sore throat，nasal congestion and runny nose in the observation group was shorter(P＜0.05). After treatment，the serum hs-CRP levels in the two groups were decreased when compared with those before treatment(P＜0.05)，and the serum hs-CRP level in the observation group was lower than that in the control group(P＜0.05). Conclusion：Xiaoer Chaigui Tuire granules combined with oseltamivir phosphate for influenza in children can effectively improve clinical symptoms and reduce inflammatory reactions， with relatively high safety.