基于数据挖掘分析子宫颈上皮内瘤变中医组方用药规律
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R711.74

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江苏省自然科学基金项目(BK20211327);国家自然科学基金项目(82174432);江苏省中医药管理局科技专项(2020ZX21);扬州 大学‘青蓝工程’项目(YZ2017074)


Analysis of Administration Rules of Chinese Medicine Prescriptions for Cervical Intraepithelial Neoplasia Based on Data Mining
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    摘要:

    目的:运用现代数据挖掘技术分析、总结中医药在治疗子宫颈上皮内瘤变的组方用药规律。方法:收集中国知网(CNKI) 和万方数据库自建库至2021 年2 月1 日期间发表的关于中医药治疗子宫颈上皮内瘤变的相关文献,运用中医传承辅助系统V2.5 统计文献中出现中药的频次、功效、性味、归经等,通过关联规则、改进的互信息法以及熵聚类分析法对出现药物的关联规则及新方组合进行客观分析,采用无监督熵层次聚类对新处方进行分析。结果:共纳入复方89 首,共计中药162 味,使用频次最高的前5 味中药分别为黄柏、冰片、土茯苓、薏苡仁和白花蛇舌草,重在清热与祛湿。四气则以寒占绝对优势,五味则以苦、甘、辛味为主,而归经又以肝、脾、胃为主。利用关联规则挖掘得到新方组合4 个,高频药物组合20 个。结论:中医药治疗子宫颈上皮内瘤变主要责之湿邪,病变涉及肝、脾、胃三脏,湿与热经常合并出现,组方治疗多以清热解毒、健脾燥湿药为主。

    Abstract:

    Abstract: Objective: To analyze and summarize the prescriptions and administration rule of Chinese medicine in the treatment of cervical intraepithelial neoplasia by using modern data mining technology. Methods:Relevant literatures on the treatment of cervical intraepithelial neoplasia with Chinese medicine published by CNKI and Wanfang databases from database establishment to February 1,2021 were collected,and the frequency,effect,nature and flavor,and meridian entry of Chinese herbs in literatures were counted by TCM Inheritance Assistance System V2.5. The methods of association rule, improved mutual information and entropy clustering were used to objectively analyze the association rules and new prescriptions of emerging herbs, and unsupervised entropy hierarchical clustering method was used to analyze new prescriptions. Results:A total of 89 prescriptions were enrolled,including 162 Chinese herbs. The top five herbs with the highest frequency were Cortex Phellodendri Chinensis,Borneolum Syntheticum,Rhizoma Smilacis Glabrae,Semen Coicis and Herba Hedyotis Diffusae,whose effect is mainly clearing heat and dispelling dampness. In terms of four qi,the cold is dominated;in terms of five flavors,the bitter,sweet and pungent are dominated. In terms of meridian entry,the meridian enters into the liver,spleen and stomach. Four new prescriptions and 20 high-frequency herbal combinations were obtained by association rule mining. Conclusion: The main pathogenesis of cervical intraepithelial neoplasia in Chinese medicine is pathogenic dampness,which is associated with the dysfunction of the liver,spleen and stomach. Pathogenci dampness and heat often appear together. The prescriptions mainly include herbs for clearing heat and resolving toxins,fortifying the spleen and drying dampness.

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杨晗,林飞,陈媛媛,陈婷婷,刘小琴,崔树娜.基于数据挖掘分析子宫颈上皮内瘤变中医组方用药规律[J].新中医,2021,53(22):120-124

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  • 在线发布日期: 2021-11-26
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