Abstract： Multiple sclerosis reflects in complex symptoms and is easy to relapse with no obvious regularity， and its clinical treatment is very difficult. Prof. ZHANG Lei，a master of Chinese medicine，believes that blood stasis is not only a pathological product but also a pathogenic factor in the course of multiple sclerosis based on the theory of “long- course illness leading to stasis”. In clinical practice， he creates his Blood Stasis Theory， and treats the disease according to syndrome differentiation from the aspects of qi constraint transforming into fire，qi deficiency，phlegm-damp and binding of static heat，and obtains a good effect.