Abstract：Objective：To observe the control effect of modified Shenqi Dihuang tang combined with irbesartan tablets on urinary protein and blood pressure in patients with hypertensive nephropathy. Methods：A total of 80 cases of patients with hypertensive nephropathy were selected and divided into the control group and the observation group according to different treatment methods，with 40 cases in each group. The control group was treated with irbesartan tablets，and the observation group was additionally treated with modified Shenqi Dihuang tang based on the treatment of the control group. Both groups were treated for 12 weeks. Before and after treatment，the changes of indexes of blood pressure，the kidney function and urinary protein were observed. Results：After treatment，the total effective rate was 82.5% in the observation group，higher than that of 72.5% in the control group(P＜0.05). After treatment，the systolic and diastolic blood pressure，urinary albumin excretion(UAE)， plasma cystatin C(CysC) as well as levels of blood urea nitrogen(BUN)，urinary microalbumin(mAlb)，serum creatinine(SCr)，and β2-microglobulin(β2-MG) in the two groups were decreased when compared with those before treatment (P＜0.05)，and the glomerular filtration rate(GFR) was increased(P＜0.05)；the systolic and diastolic blood pressure，UAE， plasma CysC as well as levels of BUN，urinary mAlb，SCr，and β2- MG in the observation group were lower than those in the control group(P＜0.05)， and the GFR was higher(P＜0.05). Conclusion： Modified Shenqi Dihuang tang combined with irbesartan tablets can effectively improve the index of albumin and the kidney function as well as reduce the blood pressure in patients with hypertensive nephropathy.