Abstract： Objective： To observe the clinical effect of urinarykallid injection combined with Xinnao Fujian granules for acute cerebral infarction and its effect on levels of high- sensitivity C- reactive protein(hs- CRP) and interleukin- 6(IL- 6) in serum. Methods： A total of 90 cases of patients with acute cerebral infarction were divided into the control group and the study group according to the random number table method，with 45 cases in each group. Both groups were routinely given basic treatment for acute ischemic stroke； the control group was additionally treated with urinarykallid injection， and the study group was additionally treated with Xinnao Fujian granules based on the treatment of the control group. Both groups were treated for 21 days. The clinical effects in the two groups were compared. Before and after treatment，the changes in scores of National Institutes of Health Stroke Scale(NIHSS) and activities of daily living in Barthel Index(BI) as well as levels of hs-CRP and IL-6 in serum in the two groups were observed. Results：The total effective rate of clinical effect was 95.56% in the study group and 82.22% in the control group， the difference being significant(P＜0.05). After treatment， the NIHSS scores in the two groups were decreased when compared with those before treatment and the BI scores were increased， and the NIHSS score in the study group was lower than that in the control group and BI score was higher，differences being significant(P＜0.05). After treatment， the levels of hs- CRP and IL- 6 in serum in the two groups were decreased when compared with those before treatment， and the above two levels in the study group were lower than those in the control group，differences being significant(P＜0.05). During observation，in the study group，there was one case of blood pressure drop， one dizziness， one abdominal distension and one nausea， the incidence of adverse reactions being 8.89% ； in the control group，there was one case of blood pressure drop，one dizziness，two nausea and one abdominal distension，the incidence of adverse reactions being 11.11%. There was no significant difference being found in the comparison of incidences of adverse reactions between the two groups(P＞0.05). Conclusion： Urinarykallid injection combined with Xinnao Fujian granules has a significant clinical effect in treating acute cerebral infarction， and can improve the symptoms of neurologic impairment of patients，relieve inflammatory responses and improve activities of daily living.