Abstract：Objective：To observe the clinical effect of the therapy of Chuanxiong Longzhi tang combined with western medicine on acute cerebral infarction(ACI) with static phlegm obstructing the collaterals syndrome. Methods ： A total of 80 patients with ACI were selected and divided into the control group and the observation group according to the random number table method，with 40 cases in each group. The control group was treated with routine western medicine，and the observation group was additionally treated with Chuanxiong Longzhi tang based on the treatment of the control group. The changes of scores of Barthel Index(BI) and National Institutes of Health Stroke Scale(NIHSS)，and levels of peak blood flow velocity of bilateral common carotid artery， mean peak blood flow velocity of cerebral artery， serum vascular endothelial growth factor(VEGF) and angiopoietin- 2(Ang- 2)， and hypoxia- inducible factor- 1α(HIF- 1α) in the two groups before and after treatment were observed，and the clinical effects were evaluated. Results：The total effective rate was 92.50% in the observation group， higher than that of 55.00% in the control group(P＜0.05). After treatment， the BI scores in the two groups were increased when compared with those before treatment， and the NIHSS scores were decreased， and the changes of the above scores in the observation group were greater than those in the control group， the difference being significant(P＜0.05). After treatment，the levels of VEGF and Ang-2 in the two groups were increased when compared with those before treatment， and the level of HIF- 1α was decreased， and the changes of the above levels in the observation group were greater than those in the control group(P＜0.05). After treatment，the levels of peak blood flow velocity of bilateral common carotid artery and mean peak blood flow velocity of cerebral artery in the two groups were increased when compared with those before treatment，and the above levels in the observation group were higher than those in the control group(P＜ 0.05). Conclusion：The therapy of Chuanxiong Longzhi tang combined with western medicine has a definite curative effect on patients with ACI with static phlegm obstructing the collaterals syndrome，which can improve the neurological function and activity ability of daily living of patients，and its mechanism may be related to the promotion of angiogenesis.