Abstract：Objective：To observe the clinical effect of Qingre Qushi Lidan tang combined with western medicine for viral hepatitis. Methods：A total of 98 cases of patients with viral hepatitis of liver-gallbladder dampness-heat type were selected and divided into the control group and the observation group according to the random number table method，with 49 cases in each group. The control group was given routine treatment with diammonium glycyrrhizinate enteric- coated capsules and entecavir dispersible tablets，and the observation group was additionally treated with Qingre Qushi Lidan tang based on the treatment of the control group. Both groups were treated for three months. Clinical effects in the two groups were observed. Before and after treatment， Chinese medicine syndrome scores and the liver function [alanine aminotransferase(ALT)， aspartate aminotransferase(AST)，γ-glutamyltransferase(γ-GT)，total bilirubin(TBil) and direct bilirubin(DBil)] were compared between the two groups. After treatment，incidence of adverse reactions was observed in the two groups. Results：After treatment，Chinese medicine syndrome scores of pain in ribs，bitter taste in the mouth and dry mouth，poor appetite，and fatigue and lack of strength in the two groups were decreased when compared with those before treatment，and the above four scores in the observation group were lower than those in the control group，differences being significant(P＜0.05). After treatment，the total effective rate of clinical effect was 89.80% in the observation group，higher than that of 69.39% in the control group，the difference being significant(P＜0.05). After treatment，levels of ALT，AST，γ-GT，TBil，and DBil in the two groups were decreased when compared with those before treatment，and the above five levels in the observation group were lower than those in the control group，differences being significant(P＜0.05). The incidence of adverse reactions was 10.20% in the observation group and 28.57% in the control group，the difference being significant(P＜0.05). Conclusion：The therapy of Qingre Qushi Lidan tang combined with western medicine for viral hepatitis of liver- gallbladder dampness- heat type can improve the liver function and relieve clinical symptoms with high medication safety.