Abstract： Objective： To observe the clinical effect of the therapy of Kangfuxin solution combined with BCG polysaccharide and nucleic acid injection on the treatment of erosive oral lichen planus and its effect on immune function. Methods：A total of 72 erosive oral lichen planus patients were divided into the control group and the observation group by random number table， 36 cases in each group. The control group was treated with BCG polysaccharide and nucleic acid injection，and the observation group was additionally treated with Kangfuxin solution based on the treatment of the control group. The changes in the levels of relevant inflammatory factors in saliva including albumin(Alb)，interleukin- 10(IL-10) and interferon-γ(IFN-γ)，immunoglobulins in serum including immunoglobulin A(IgA)，immunoglobulin G(IgG) and immunoglobulin M(IgM) were observed before and after treatment. The clinical effect and adverse reactions in the two groups were evaluated. Results：The total effective rate was 94.44% in the observation group，significantly higher than that of 77.78% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference in the levels of Alb， IFN- γ and IL- 10 in saliva between the two groups(P＞0.05). After treatment，the levels of Alb and IL- 10 in saliva in both groups were decreased when compared with those before treatment，and the levels of IFN-γ were increased；the levels of Alb and IL- 10 in saliva in the observation group were lower than those in the control group， and the level of IFN- γ was higher；differences were significant(P＜0.05). Before treatment，there was no significant difference in the immunoglobulin levels between the two groups(P＞0.05). After treatment，the levels of IgA，IgG and IgM in the two groups were higher than those before treatment， and the above levels in the observation group were higher than those in the control group， differences being significant(P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups(χ 2=0.158， P=0.691). Conclusion： The therapy of Kangfuxin solution combined with BCG polysaccharide and nucleic acid injection has a significant therapeutic effect on erosive oral lichen planus patients，which can effectively regulate the level of relevant inflammatory factors in the saliva of patients，improve the body immunity and is worthy of promotion.