益气健脾汤联合化疗对结肠癌患者根治术后疗效的影响
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R735.35;R574.2

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Curative Effect of Yiqi Jianpi Tang Combined with Chemotherapy on Patients with Colon Cancer After Radical Treatment
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    摘要:

    目的:观察益气健脾汤联合化疗对结肠癌患者根治术后临床疗效的影响。方法:将60 例结肠癌根治术后患者按随机数字表法分为观察组与对照组各30 例。对照组采用化疗治疗,观察组采用益气健脾汤联合化疗治疗。比较2 组临床总有效率,比较2 组治疗前后生活质量、疼痛程度、睡眠质量、中医证候积分、肿瘤标志物及炎性因子水平。结果:观察组总有效率83.33%,高于对照组60.00%(P<0.05)。与同组治疗前比较,治疗后2 组生活质量评分表(QOL) 评分升高(P<0.05),视觉模拟评分法(VAS) 评分、匹兹堡睡眠质量指数(PSQI) 评分、中医证候积分及血清糖类抗原199(CA199)、癌胚抗原(CEA)、白细胞介素-6(IL-6)、肿瘤坏死因子-ɑ(TNF-ɑ) 水平均降低(P<0.05);与对照组治疗后比较,观察组治疗后QOL 评分较高(P<0.05),VAS 评分、PSQI 评分、中医证候积分及血清CA199、CEA、IL-6、TNF-ɑ 水平均较低(P<0.05)。结论:益气健脾汤联合化疗治疗结肠癌根治术后的疗效较好,可改善患者的生活质量及中医证候,降低疼痛程度,提高睡眠质量,这可能与降低肿瘤标志物、炎性因子水平有关。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Yiqi Jianpi tang combined with chemotherapy on patients with colon cancer after radical treatment. Methods:A total of 60 cases of patients with colon cancer after radical treatment were divided into the observation group and the control group according to the random number table method, with 30 cases in each group. The control group was given chemotherapy, and the observation group was treated with Yiqi Jianpi tang combined with chemotherapy. The total clinical effective rates in the two groups were compared. Before and after treatment, the quality of life,pain degree,sleep quality,Chinese medicine syndrome scores,tumor markers and inflammatory factors levels in the two groups were compared. Results:The total effective rate was 83.33% in the observation group,higher than that of 60.00% in the control group(P<0.05). After treatment,the scores of Quality of Life(QOL) scale in the two groups were increased when compared with those before treatment(P<0.05),and the scores of Visual Analogue Scale(VAS),Pittsburgh Sleep Quality Index(PSQI) and Chinese medicine syndromes as well as levels of Carbohydrate antigen 199(CA199), carcinoembryonic antigen(CEA),interleukin- 6(IL- 6) and tumor necrosis factor- α(TNF- α) in serum in the two groups were decreased(P<0.05); the QOL score in the observation group was higher than that in the control group(P<0.05), and the scores of VAS,PSQI and Chinese medicine syndromes as well as the levels of CA199,CEA,IL- 6 and TNF-ɑ in serum were lower(P<0.05). Conclusion:Yiqi Jianpi tang combined with chemotherapy has a good curative effect for patients with colon cancer after radical treatment,and can improve their quality of life and Chinese medicine syndromes,relieve pain and promote sleep quality,which may be related to reduction of levels of tumor markers and inflammatory factors.

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陈朝阳,何家辉,陈玉琼.益气健脾汤联合化疗对结肠癌患者根治术后疗效的影响[J].新中医,2021,53(23):159-162

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  • 在线发布日期: 2021-12-10
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