加味龙胆泻肝汤联合刺络放血疗法治疗带状疱疹临床研究
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Clinical Study on Modified Longdan Xiegan Tang Combined with Blood- Letting Puncture Therapy for Herpes Zoster
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    摘要:

    目的:观察加味龙胆泻肝汤联合刺络放血疗法治疗带状疱疹的临床疗效。方法:选取带状疱疹患者120 例,按照随机数字法分为观察组和对照组各60 例。对照组给予氯雷他定片口服联合糠酸莫米松乳膏外用治疗,观察组采用加味龙胆泻肝汤内服联合刺络放血疗法治疗。2 组均以2 周为1 个疗程,共治疗2 个疗程。观察比较2 组治疗前后血清肿瘤坏死因子-α(TNF-α)、免疫球蛋白E(IgE)、白细胞介素-12(IL-12) 及T 细胞亚群(CD3+、CD4+、CD8+) 水平。结果:观察组总有效率为100%,照组为93.33%,2 组比较,差异有统计学意义(P<0.05)。治疗前,2 组TNF-α、IgE、IL-12 水平比较,差异无统计学意义(P>0.05);治疗后,2 组TNF-α、IgE 水平均较治疗前降低(P<0.05),IL-12 水平较治疗前升高(P<0.05);且观察组各项指标改善较对照组更显著(P<0.05)。治疗前,2 组CD3+、CD4+、CD8+水平比较,差异无统计学意义(P>0.05);治疗后,2 组CD3+、CD4+水平均较治疗前升高(P<0.05)、CD8+水平较治疗前降低(P<0.05),且观察组各项指标改善较对照组更显著(P<0.05)。结论:加味龙胆泻肝汤联合刺络放血疗法治疗带状疱疹疗效肯定,可有效改善机体免疫功能,控制炎症反应,从而改善病情。

    Abstract:

    Abstract: Objective: To observe the clinical effect of modified Longdan Xiegan tang combined with blood- letting puncture therapy for herpes zoster. Methods:A total of 120 cases of patients with herpes zoster were selected and divided into the observation group and the control group according to the random number method,with 60 cases in each group. The control group was given the oral administration of loratadine tablets combined with external application of mometasone furoate cream,and the observation group was given the oral administration of modified Longdan Xiegan tang combined with bloodletting puncture therapy. Both groups were treated for two courses, with two weeks being a course. Before and after treatment,the levels of tumor necrosis factor-α(TNF-α),immunoglobulin E(IgE),interleukin-12(IL-12) and T cell subsets including CD3+,CD4+ and CD8+ in the two groups were observed and compared. Results:The total effective rate was 100% in the observation group and 93.33% in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of the levels of TNF-α,IgE and IL-12 between the two groups (P>0.05). After treatment,the levels of TNF-α and IgE in the two groups were decreased when compared with those before treatment(P<0.05), and the levels of IL- 12 were increased(P<0.05); the improvement of the above indexes in the observation group was more significant than that in the control group(P<0.05). Before treatment,there was no significant difference being found in the comparison of the levels of CD3 + , CD4 + and CD8 + between the two groups(P>0.05). After treatment,the levels of CD3+ and CD4+ in the two groups were increased when compared with those before treatment(P< 0.05),and the levels of CD8+ were decreased(P<0.05);the improvement of each index in the observation group was more significant than that in the control group(P<0.05). Conclusion:Modified Longdan Xiegan tang combined with blood- letting puncture therapy for herpes zoster has a definite curative effect,and can effectively improve the immune function of the body and control the inflammatory response,thus improving the condition.

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刘艳,刘娟云,张楠.加味龙胆泻肝汤联合刺络放血疗法治疗带状疱疹临床研究[J].新中医,2021,53(24):27-30

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  • 在线发布日期: 2021-12-27
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