Abstract： Objective： To observe the clinical effect of Zhike Pingchuan Shierwei mixture for cough- variant asthma of phlegm-heat obstructing the lung type and its effect on the lung function as well as immunoglobulin E(IgE)，tumor necrosis factor- α(TNF- α) and interleukin- 8(IL- 8) in peripheral blood. Methods： A total of 92 cases of patients with cough- variant asthma who were treated in the Respiratory Department from September 2018 to August 2020 and met the research conditions were randomly divided into two groups， with 46 cases in each group. The control group was treated with montelukast sodium combined with doxofylline， and the observation group was additionally treated with Zhike Pingchuan Shierwei mixture based on the treatment of the control group. Both groups were treated for two weeks. Before and after treatment，scores of cough and cough-related quality of life，the lung function indexes，as well as IgE，TNF-α and IL-8 in peripheral blood were compared between the two groups. Results： After two- week treatment， the symptom score of cough in the observation group was lower than that in the control group(P＜0.05)；the score of cough-related quality of life was higher than that in the control group(P＜0.05)；the indexes of the lung function including the forced expiratory volume in one second(FEV1)，peak expiratory flow(PEF) and maximal mid-expiratory flow rate(MMEF75/25) in the observation group were higher than those in the control group(P＜0.05)； IgE， TNF- α and IL- 8 in peripheral blood in the observation group were lower than those in the control group(P＜0.05). Conclusion： For patients with cough- variant asthma of phlegm- heat obstructing the lung type， Zhike Pingchuan Shierwei mixture can significantly reduce levels of inflammatory factors in peripheral blood，such as IgE，TNF- α and IL- 8，improve the lung function and cough- related quality of life，and relieve symptoms of cough.