Abstract：Objective：To observe the effect of Shenqi Fuzheng tang combined with apatinib for advanced colon cancer. Methods： A total of 82 cases of patients with advanced colon cancer of spleen qi deficiency type were divided into the treatment goup and the control group，with 41 cases in each group. Both groups were given symptomatic treatment including liver protection， antiemetics and nutrition support， as well as the oral administration of apatinib mesylate tablets； the treatment group was additionally treated with Shenqi Fuzheng tang. Both groups were treated for four weeks. Before treatment and after four- week treatment，the scores of Chinese medicine syndromes，Functional Assessment of Cancer Treatment-colon cancer(FACT-C) and Karnofsky Performance Scale(KPS) as well as the levels of CD4+/CD8+ ratio and T cell subsets including peripheral blood T lymphocytes CD3+，helper T cells CD4+ and cytotoxic T cells CD8+ in the two groups were compared. Curative effects and incidences of adverse reactions in the two groups were compared. Results：After four weeks of treatment，the total clinical effective rate in the treatment group was higher than that in the control group(P＜0.05). The scores of abdominal distention and fullness，poor appetite，sloppy stool，fatigue in limbs，and lassitude of spirit and lack of strength in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above five syndrome scores in the treatment group were lower than those in the control group(P＜0.05). The levels of CD3+，CD4+ and CD4+/CD8+ ratio in the two groups were increased when compared with those before treatment，and the levels of CD8+ were decreased，differences being significant(P＜0.05). The levels of CD3+，CD4+ and CD4+/CD8+ ratio in the treatment group were higher than those in the control group， and CD8 + level was lower， differences being significant(P＜0.05). The scores of FACT- C and KPS in the two groups were increased when compared with those before treatment， differences being significant(P＜0.05). The scores of FACT- C and KPS in the treatment group were higher than those in the control group， differences being significant(P＜0.05). There was no significant difference being found in the comparison of the incidences of adverse reactions between the two groups(P＞0.05). Conclusion： The therapy of Shenqi Fuzheng tang combined with apatinib for patients with advanced colon cancer of spleen qi deficiency type can significantly relieve their clinical symptoms， improve the immune function，and enhance their quality of life，with a good curative effect and high safety.