Abstract：Objective：To observe the effect of Bupi Yiqi Huangqi porridge on quality of life in patients with cancer-related fatigue(CRF) receiving chemotherapy for non- small cell lung cancer(NSCLC) at advanced stage of lung- spleen qi deficiency type. Methods： A total of 70 cases of CRF patients receiving NSCLC chemotherapy at advanced stage of lung- spleen qi deficiency type who were in accordance with the inclusive criteria were randomly divided into two groups，with 35 cases in each group. The control group was given routine treatment and nursing，and the observation group was additionally treated with Bupi Yiqi Huangqi porridge based on the treatment of the control group. Before and after intervention， the scores of Hospital Anxiety and Depression Scale(HADS)，Pittsburgh Sleep Quality Index(PSQI) and European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire(EORTC QLQ- C30) in the two groups were compared. Results： After intervention，the HADS scores，the section scores and the total scores of PSQI and the scores of EORTC QLQ-C30 including physical，role and emotional functions and fatigue，pain，panting and insomnia symptom scores in the observation group were lower than those in the control group(P＜0.05)；there was no significant difference being found in the comparison of scores of cognitive function，social function and overall health between the two groups(P＞0.05). Conclusion：Bupi Yiqi Huangqi porridge can relieve negative emotions in CRF patients receiving NSCLC chemotherapy at advanced stage of lungspleen qi deficiency type，and improve their sleep quality and quality of life.