Abstract：Objective：To observe the effect of early lung rehabilitation combined with Chinese medicine nursing on lung function and exercise endurance of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods： A total of 91 cases of patients with AECOPD were randomly divided into the control group and the observation group according to the random number table method，with 45 cases and 46 cases in each group respectively. Both groups were given symptomatic treatments；the control group was given routine nursing intervention，and the observation group was additionally given early lung rehabilitation combined with Chinese medicine nursing intervention based on the treatment of the control group. After three- month nursing intervention， the lung function， exercise endurance and muscle strength indexes，and scores of quality of life and dyspnea in the two groups before and after intervention were compared；during one-year follow-up，the number of acute attacks in the two groups was counted. Results：Before intervention，there was no significant difference being found in the comparison of levels of forced vital capacity(FVC)，forced expiratory volume in one second(FEV1)，ratio of forced expiratory volume to forced vital capacity in one second(FEV1%) and FEV1/FVC between the two groups(P＞0.05)； after intervention， the above levels in the observation group were significantly higher than those in the control group，differences being significant(P＜0.05). Before intervention，there was no significant difference being found in the comparison of indexes of exercise endurance and muscle strength between the two groups(P＞0.05)；after intervention， the six minute walk test(6MWD)， peak oxygen uptake， peak respiratory exchange ratio， number of sit- stard times completed in 60 seconds(STS-60) value in the observation group were higher than those in the control group，and time needs to complete 5 times sit- stard(STS- 5) value was lower， differences being significant(P＜0.05). Before intervention， there was no significant difference being found in the comparison of scores of medical research council dyspnea scale(MRC) and comprehensive assessment of COPD(CAT) between the two groups(P＞0.05)； after intervention， the above scores in the observation group were significantly lower than those in the control group，differences being significant(P＜0.05). During one year of follow- up， the number of acute attacks in the observation group was lower than that in the control group， the difference being significant(P＜0.05). Conclusion： Early lung rehabilitation combined with Chinese medicine nursing can effectively improve the lung function and quality of life of patients with acute exacerbation of chronic obstructive pulmonary disease，enhance their exercise endurance and skeletal muscle strength，and reduce the frequency of acute attack.