Abstract：Objective：To observe the curative effect and safety of Ganmai Dazao tang and cognitive behavioral therapy combined with risperidone on schizophrenia. Methods：A total of 120 cases of patients with schizophrenia were selected as the study subjects and were divided into the study group and the control group according to different treatment methods， with 60 cases in each group. The control group was treated with risperidone，and the study group was additionally treated with Ganmai Dazao tang and cognitive behavioral therapy based on the treatment of the control group. Scores of Krawiecka Symptom Scale and Social Dysfunction Rating Scale(SDRS) before and after treatment as well as clinical effects were compared between the two groups. The incidence of adverse reactions was counted. Results：The total effective rate was 88.33% in the study group，higher than that of 75.00% in the control group，the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of scores of Krawiecka Symptom Scale and SDSS between the two groups(P＞0.05). After treatment， scores of Krawiecka Symptom Scale in the two groups were decreased when compared with those before treatment，and the score in the study group was lower than that in the control group(P＜0.05)；scores of SDSS in the study group was lower than that before treatment and that in the control group，the difference being significant(P＜0.05). The incidence of adverse reactions was 20.00% in the study group，lower than that of 35.00% in the control group， the difference being significant(P＜0.05). Conclusion： Ganmai Dazao tang and cognitive behavioral therapy combined with risperidone can effectively improve the clinical effect on patients with schizophrenia， promote the recovery of their mental status and social function，and reduce the incidence of adverse reactions.