Abstract：Objective：To observe the syndrome factors of Chinese medicine staging diagnosis of acute myeloid fatigue， and to clarify its evolution law of syndrome types. Methods：A total of 92 cases with acute myeloid fatigue were recorded， and the clinical syndromes of them were collected before treatment， three months after treatment and six months after treatment. At the same time， Chinese medicine syndrome differentiation was performed according to the theory of "three stages and four types". ROC analysis was carried out via SPSS17.0 statistical software to process and analyze the data. Results：At the initial stage，43 patients had clinical syndrome characteristics consistent with the type of excessive heat and toxin accumulation， and 49 patients had clinical syndrome characteristics consistent with the type of yin deficiency and excessive fire；the clinical syndrome characteristics of 92 patients in the middle stage were consistent with the type of both qi and yin deficiency，and the late stage of 92 cases of clinical syndrome characteristics were consistent with the type of yin and yang deficiency. The main syndromes of the type of excessive heat and toxin obstruction include strong heat，flushed face， bleeding，dizziness，yellow urine，red tongue，and thin yellow coating；secondary syndromes are fatigue and weakness， dry stools，thirst，little sleep and many dreams. The main syndromes of the type of yin deficiency and excessive fire include pale face， red zygomatic， dry mouth and tongue， bleeding， dizziness， fatigue and weakness， tinnitus， red and purple tongue， and few coating； secondary syndromes are night sweat， palpitations， tendency to worry， hot middle parts of hands and feet， and yellow urine. The main syndromes of the type of both qi and yin deficiency include pale face， tired appearance，chest distress，palpitations，tendency to worry，spontaneous sweat，and hot middle parts of hands and feet； secondary syndromes are night sweat，poor appetite，short breath，aversion to chills and winds. The main syndromes of the type of yin and yang deficiency include pale face，from-time-to-time cold and hot feelings，little sleep and many dreams， spontaneous sweat，sore and weak waists and knees，pale and enlarged tongue，and thin and white coating；secondary syndromes are night sweat，cold body and limbs，loose stools. Conclusion：The evolution law of syndrome types is from the type of excessive heat and toxin accumulation or the type of yin deficiency and excessive fire，to the type of both qi and yin deficiency or the type of yin and yang deficiency. The criteria of Chinese medicine staging diagnosis of acute myeloid fatigue has been preliminarily formed.