Abstract： Objective： To observe the effect of the therapy of Yiqing tablets combined with tinidazole tablets on high mobility group B1(HMGB1) proteins，high mobility group A1(HMGA1) proteins and liver metabolism in patients with metabolic associated fatty liver disease(MAFLD) complicated with periodontitis. Methods： A total of 95 MAFLD patients complicated with chronic periodontitis were selected as the MAFLD complicated with periodontitis group， 100 patients with chronic periodontitis as the periodontitis group，and 100 people with normal physical examination results as the healthy group. The MAFLD complicated with periodontitis group and the periodontitis group were treated with oral administration of Yiqing tablets combined with tinidazole tablets for four weeks. Before and after treatment，the Plaque Index(PLI)，Sulcus Bleeding Index (SBI)，Clinical Attachment Loss(CAL)，periodontal probing depth(PD)，triglyceride(TG)，total cholesterol(TC) and low-density lipoprotein cholesterol(LDL-C) in the MAFLD complicated with periodontitis group and the periodontitis group were compared. The relative expressions of HMGA1 and HMGB1 proteins in the three groups were detected by Western Blot. Results：Before treatment，the relative expressions of HMGB1 and HMGA1 proteins in the MAFLD complicated with periodontitis group and the periodontitis group were increased when compared with those in the healthy group(P＜0.05). After treatment，the levels of PLI，SBI，LDL- C，TC and TG and the relative expressions of HMGB1 and HMGA1 proteins in the MAFLD complicated with periodontitis group and the periodontitis group were decreased when compared with those before treatment(P＜0.05)， and CAL and PD became shallower(P＜0.05)；before treatment，the levels of PLI and SBI and relative expressions of HMGB1 and HMGA1 proteins in the periodontitis group were lower than those in the MAFLD complicated with periodontitis group(P＜ 0.05)，and CAL and PD were shallower(P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of LDL-C，TC and TG in the periodontitis group and the MAFLD complicated with periodontitis group(P＞ 0.05)；after treatment，there was no significant difference being found in the comparison of levels of LDL- C，TC and TG between the periodontitis group and the MAFLD complicated with periodontitis group(P＞0.05). Conclusion：The therapy of Yiqing tablets combined with tinidazole tablets for MAFLD patients complicated with periodontitis has a significant curative effect， which can significantly improve the periodontal indexes of patients， and effectively reduce the inflammatory responses of MAFLD.