Abstract： Objective： To observe the clinical effect of Shenshuaining capsules combined with calcium carbonate for maintenance hemodialysis(MHD) complicated with hyperphosphatemia. Methods：A total of 60 cases of patients with MHD complicated with hyperphosphatemia were selected and divided into the observation group and the control group according to the random number table method，with 30 cases in each group. Both groups were given routine hemodialysis；the control group was treated with hyperphosphatemia，and the observation group was treated with Shenshuaining capsules combined with calcium carbonate；both groups were treated for three months. Changes in blood calcium(Ca)，phosphorus(P)，calciumphosphorus product(Ca×P) as well as the levels of creatinine，urea nitrogen，hemoglobin，albumin and intact parathyroid hormone(iPTH) before and after treatment were compared between the two groups. Results： Before treatment， when compared levels of hemoglobin，albumin，creatinine and urea nitrogen between the two groups，there was no significance in the difference(P＞0.05). After treatment， blood albumin and hemoglobin in the observation group were significantly increased when compared with those before treatment and were obviously higher than those in the control group， differences being significant(P＜0.05). Before treatment，when compared levels of Ca，P，Ca×P and iPTH in blood between the two groups，there was no significance in the difference(P＞0.05). After treatment，the levels of P and Ca×P in blood in the two groups were decreased when compared with those before treatment，and the two levels in the observation group were lower than those in the control group，the difference being significant(P＜0.05). After treatment，level of iPTH in serum in the observation group was lower than that before treatment and that in the control group，the difference being significant (P＜0.05). Conclusion： The therapy of Shenshuaining capsules combined with calcium carbonate for patients with MHD complicated with hyperphosphatemia can effectively reduce levels of blood P， Ca × P and iPTH， and improve nutritional status and renal anemia with good medication safety.