施氏伤科吊伤膏联合消肿解毒汤治疗急性痛风性关节炎临床研究
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R589.7

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上海市中医诊疗模式创新试点建设项目[ZY(2018-2020)-FWTX-6016];上海市黄浦区科研项目(HKQ201812)


Clinical Study on SHI's Shangke Diaoshang Ointment Combined with Xiaozhong Jiedu Tang for Acute Gouty Arthritis
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    摘要:

    目的:观察施氏伤科吊伤膏外敷联合消肿解毒汤内服治疗急性痛风性关节炎(AGA) 的临床疗效。方法:将70 例AGA 患者按随机数字表法分为治疗组及对照组各35 例。2 组均给予生活方式指导,治疗组给予外敷施氏伤科吊伤膏联合自拟消肿解毒汤口服,对照组口服双氯芬酸钠双释放肠溶胶囊,2 组均连续治疗7 d。观察2 组临床疗效,比较2 组治疗前后关节疼痛视觉模拟评分法(VAS) 评分、关节红肿、关节活动评分及实验室指标[血尿酸(BUA)、血沉(ESR)、C-反应蛋白(CRP)]变化,观察2 组治疗期间不良反应情况。结果:治疗后,2 组关节红肿评分、关节活动评分、VAS 评分均较治疗前降低(P<0.05),治疗组上述3 项评分均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2 组BUA、ESR、CRP 均较治疗前降低(P<0.05),治疗组上述3 项均低于对照组,但仅BUA 差异有统计学意义(P<0.05)。治疗组总有效率为91.43%,高于对照组62.86%,2 组比较,差异有统计学意义(P<0.05)。治疗期间,治疗组35 例均未出现明显不良反应,对照组出现1 例胃痛,停药后症状缓解。结论:施氏伤科吊伤膏外敷联合消肿解毒汤内服治疗AGA 能有效缓解临床症状,用药安全性较高。

    Abstract:

    Abstract: Objective: To observe the clinical effect of the therapy of external application of SHI's Shangke Diaoshang ointment combined with Xiaozhong Jiedu tang on acute gouty arthritis(AGA). Methods:A total of 70 patients with AGA were divided into the treatment group and the control group according to the random number table method, with 35 cases in each group. Both groups were given lifestyle guidance. The treatment group was additionally given external application of SHI's Shangke Diaoshang ointment combined with self-made Xiaozhong Jiedu tang,and the control group was additionally given diclofenac sodium dual release enteric-coated capsules. Both groups were treated for seven days. The clinical effects in the two groups were observed. Before and after treatment,the scores of Visual Analogue Scale(VAS) for joint pain,scores of joint swelling and joint activity and changes of laboratory indexes,including blood uric acid(BUA),erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) in the two groups were compared. During treatment,the adverse reactions in the two groups were observed. Results:After treatment,the scores of joint swelling,joint activity and VAS in the two groups were decreased when compared with those before treatment(P<0.05),and the above three scores in the treatment group were lower than those in the control group,differences being significant(P<0.05). After treatment,the BUA,ESR and CRP in the two groups were decreased when compared with those before treatment(P<0.05), and the above three indexes in the treatment group were lower than those in the control group, and there was significant difference being found in the comparison of BUA between the two groups(P<0.05). The total effective rate was 91.43% in the treatment group,higher than that of 62.86% in the control group,the difference being significant(P<0.05). During follow- up,no obvious adverse reactions occurred among the 35 cases in the treatment group. A case of gastric pain occurred in the control group,and the symptom was relieved after stopping treatment. Conclusion:The external application of SHI's Shangke Diaoshang ointment combined with Xiaozhong Jiedu tang for AGA can effectively alleviate clinical symptoms,with high safety.

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蒋恩宇,刘光明,杨佳裕,季伟,邵铮,詹炜祎,李辰,孙波.施氏伤科吊伤膏联合消肿解毒汤治疗急性痛风性关节炎临床研究[J].新中医,2022,54(1):108-111

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  • 在线发布日期: 2022-01-10
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