丹栀逍遥胶囊联合醋酸亮丙瑞林治疗女童特发性性早熟临床研究
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R725.8

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Clinical Study on Danzhi Xiaoyao Capsules Combined with Leuprorelin Acetate for Idiopathic Precocious Puberty in Girls
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    摘要:

    目的:观察丹栀逍遥胶囊联合醋酸亮丙瑞林治疗女童特发性性早熟的临床疗效。方法:选取90 例女童特发性性早熟患儿,按随机数字表法分为观察组和对照组各45 例。对照组给予注射用醋酸亮丙瑞林微球皮下注射治疗,观察组在对照组基础上加用丹栀逍遥胶囊治疗。比较2 组治疗前后中医证候积分、卵巢容积、子宫体积、乳腺体积、性激素[促卵泡激素(FSH)、促黄体生成素(LH)、雌二醇(E2)] 水平和左、右乳核指数,评价临床疗效。结果:观察组总有效率为91.1%,对照组为68.9%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组中医证候积分较治疗前降低,且观察组中医证候积分低于对照组,差异有统计学意义(P<0.05)。治疗后,2 组卵巢容积、子宫体积、乳腺体积较治疗前下降(P<0.05),且观察组卵巢容积、子宫体积、乳腺体积小于对照组(P<0.05)。治疗后,2 组性激素水平(FSH、LH、E2) 水平较治疗前降低(P<0.05),且观察组性激素水平(FSH、LH、E2) 水平低于对照组(P<0.05)。治疗后,2 组左、右乳核指数较治疗前降低(P<0.05),且观察组左、右乳核指数低于对照组(P<0.05)。结论:丹栀逍遥胶囊联合醋酸亮丙瑞林治疗女童特发性性早熟临床疗效显著,可有效改善患儿临床症状,降低激素水平,改善第二性征。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Danzhi Xiaoyao capsules combined with leuprorelin acetate for idiopathic precocious puberty in girls. Methods:A total of 90 cases of girls with idiopathic precocious puberty were divided into the observation group and the control group according to the random number table method,with 45 cases in each group. The control group was given subcutaneous injection with leuprorelin acetate microspheres for injection,and the observation group was additionally treated with Danzhi Xiaoyao capsules based on the treatment of the control group. Before and after treatment,Chinese medicine syndrome scores,ovarian volume,uterine volume,mammary gland volume,levels of sex hormones including follicle stimulating hormone(FSH), luteinizing hormone(LH) and estradiol(E2), and left and right mammillary nucleus indexes in the two groups were compared. The clinical effects were counted. Results:The total effective rate was 91.1% in the observation group and 68.9% in the control group, the difference being significant(P<0.05). After treatment, Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,and the score in the observation group was lower than that in the control group,the difference being significant (P<0.05). After treatment,the ovarian volume,uterine volume and mammary gland size in the two groups were decreased when compared with those before treatment(P<0.05), and the ovarian volume, uterine volume and breast size in the observation group were smaller than those in the control group(P<0.05). After treatment,levels of sex hormones including FSH, LH and E2 in the two groups were decreased when compared with those before treatment(P<0.05), and the three levels in the observation group were lower than those in the control group(P<0.05). After treatment, left and right mammillary nucleus indexes in the two groups were decreased when compared with those before treatment(P<0.05),and the two indexes in the observation group were lower than those in the control group(P<0.05). Conclusion:Danzhi Xiaoyao capsules combined with leuprorelin acetate for idiopathic precocious puberty in girls has a significant curative effect,and can effectively improve clinical symptoms,reduce hormone levels and improve secondary sex character.

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史壮丽.丹栀逍遥胶囊联合醋酸亮丙瑞林治疗女童特发性性早熟临床研究[J].新中医,2022,54(1):124-127

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  • 在线发布日期: 2022-01-10
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