基于数据挖掘的中医药治疗白血病组方用药规律分析
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Analysis of Prescription and Medication Rules of Chinese Medicine for Leukemia Based on Data Mining
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    摘要:

    目的:利用数据挖掘法研究中医药治疗白血病的用药规律,为白血病中医药临床合理用药夯实理论基石。方法:检索中国期刊全文数据库、维普中文科技期刊数据库、万方数据库自建立时间至2020 年11 月15 日期间治疗白血病的数据资料,并建立相关数据库探究其频数、频率、关联规则及聚类分析的规律。结果:合乎规则的方剂141 首,合计263 味中药,总用药频数有1 948 次,而263 味中药中使用频数前三的药物主要是黄芪、白花蛇舌草、甘草;使用频率较高的中药依次为补虚药、清热药、活血化瘀药;高频药物的性味归经主要有寒、温、平性,甘、苦、辛3 种药味以及归肝经为主;聚类树状图显示聚类关系相对突出,关联规则共得出22 对高关联药对,其中包括白术-茯苓、黄芪-白术-当归、黄芪-白术-当归-甘草等。结论:本研究符合白血病公认的本虚标实的中医病机,侧面说明其治疗应以扶正固本、祛邪解毒、活血祛瘀为主,在初步明确现代中医学者有关白血病的用药规律基础上,能更好地在中医药治疗白血病方面提供用药指导以及发掘治疗白血病新的中医处方等方面作出贡献。

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    Abstract: Objective: To study the medication rules of Chinese medicine in the treatment of leukemia by data mining method, so as to lay a theoretical foundation for the appropriate clinical application of Chinese medicine in leukemia. Methods:The data of leukemia treatment in China Journal Full- text Database,VIP Chinese Medical Journal Database and Wangfang Database from their establishment time to November 15,2020 was searched to establish relevant databases to explore their frequency,association rules and rules of cluster analysis. Results:There were 141 prescriptions in line with the rules and 263 Chinese medicines, with a total frequency of 1 948 times. The top three medicines in the 263 Chinese medicines are mainly Radix Astragali,Herba Hedyotis Diffusae and Radix et Rhizoma Glycyrrhizae. The most frequently used Chinese medicines are deficiency- tonifying medicine, heat- clearing medicine and blood- activating and stasis- resolving medicine. The natures and flavors of high-frequency medicines are mainly cold,warm,flat,sweet,bitter and acrid,and their channel entry is mainly liver meridian. The clustering tree shows that the clustering relationship is relatively prominent. A total of 22 pairs of highly correlated medicine pairs are obtained by association rules, including Rhizoma Atractylodis Macrocephalae-Poria,Radix Astragali-Rhizoma Atractylodis Macrocephalae-Radix Angelicae Sinensis,and Radix Astragali- Rhizoma Atractylodis Macrocephalae-Radix Angelicae Sinensis-Radix et Rhizoma Glycyrrhizae. Conclusion:This study is in line with the recognized Chinese medicine pathogenesis of deficient root and excess branch in leukemia. It shows that its treatment should focus on reinforcing the healthy qi and securing the root, dispelling pathogen and resolving toxins, and invigorating blood and dispelling stasis. Based on the preliminary medication rules by modern Chinese medicine scholars on leukemia, it can also contribute to providing medication guidance in the treatment of leukemia with Chinese medicine and exploring new Chinese medicine prescriptions for leukemia.

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龚恒佩,余尔慧,朱亮,颜梅,徐菲拉.基于数据挖掘的中医药治疗白血病组方用药规律分析[J].新中医,2022,54(1):140-145

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  • 在线发布日期: 2022-01-10
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