血塞通软胶囊联合醒脑静注射液治疗短暂性脑缺血临床研
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R743.31

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Clinical Study on Xuesaitong Soft Capsules Combined with Xingnaojing Injection for Transient Ischemic Attack
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    摘要:

    目的:观察血塞通软胶囊联合醒脑静注射液治疗短暂性脑缺血的临床效果。方法:选取76 例短暂性脑缺血患者作为研究对象,根据不同治疗方式分成观察组和对照组各38 例。所有患者均接受常规西药对症治疗,对照组给予醒脑静注射液治疗,观察组给予醒脑静联合血塞通软胶囊治疗。治疗2 个月后,对2 组临床疗效进行分析,并比较2 组血管内皮功能[血栓素B2(TXB2)、内皮素(ET)、一氧化氮(NO) 水平]、中国卒中量表(CSS) 评分、日常生活活动能力(ADL) 评分。结果:观察组临床总有效率为97.4%,显著高于对照组86.8%,差异有统计学意义(P<0.05)。治疗前,2 组ET、TXB2、NO 水平比较,差异无统计学意义(P>0.05)。治疗后,2 组ET、TXB2 均较治疗前降低,且观察组低于对照组;NO 水平较治疗前升高,且观察组高于对照组,差异均有统计学意义(P<0.05)。治疗前,2 组CSS、ADL 评分比较,差异无统计学意义(P>0.05)。治疗后,2 组CSS 评分较治疗前降低,且观察组低于对照组;ADL 评分均较治疗前升高,且观察组高于对照组,差异均有统计学意义(P<0.05)。结论:血塞通软胶囊联合醒脑静注射液治疗短暂性脑缺血疗效优于单纯醒脑静治疗,能够明显改善患者血管内皮功能和神经功能缺损,提高日常生活活动能力。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Xuesaitong soft capsules combined with Xingnaojing injection for transient ischemic attack. Methods:A total of 76 cases of patients with transient ischemic attack were randomly divided into the observation group and the control group according to the random number table method, with 38 cases in each group. Both groups were treated with routine symptomatic treatment of western medicine; the control group was additionally treated with Xingnaojing, and the observation group was additionally treated with Xingnaojing injection combined with Xuesaitong soft capsules. After two-month treatment,the clinical effects,the vascular endothelial function including levels of thromboxane B2(TXB2),endothelin(ET) and nitric oxide(NO),and the scores of Chinese Stroke Scale(CSS) and Activities of Daily Living(ADL) in the two groups were observed and compared. Results:The total clinical effective rate was 97.4% in the observation group and 86.8% in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of levels of ET,TXB2 and NO between the two groups(P>0.05). After treatment, the levels of ET and TXB2 in the two groups were decreased when compared with those before treatment(P< 0.05), and the levels in the observation group were lower than those in the control group(P<0.05); NO levels in the two groups were increased when compared with those before treatment(P<0.05), and the level in the observation group was higher than that in the control group(P<0.05). Before treatment, there was no significant difference being found in the comparison of scores of CSS and ADL between the two groups(P>0.05). After treatment,the CSS scores in the two groups were decreased when compared with those before treatment(P<0.05), and the CSS score in the observation group was lower than that in the control group(P<0.05); ADL scores in the two groups were increased when compared with those before treatment(P<0.05),and the ADL score in the observation group was higher than that in the control group(P<0.05). Conclusion:Xuesaitong soft capsules combined with Xingnaojing injection for transient ischemic attack has a better curative effect than that of simple Xingnaojing, which can significantly improve vascular endothelial function and nerve function defect,and enhance activities of daily living.

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黄通闹,范兴恳.血塞通软胶囊联合醒脑静注射液治疗短暂性脑缺血临床研[J].新中医,2022,54(2):53-56

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  • 在线发布日期: 2022-01-22
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