Abstract：Objective：To observe the clinical effect of Xuesaitong soft capsules combined with Xingnaojing injection for transient ischemic attack. Methods：A total of 76 cases of patients with transient ischemic attack were randomly divided into the observation group and the control group according to the random number table method， with 38 cases in each group. Both groups were treated with routine symptomatic treatment of western medicine； the control group was additionally treated with Xingnaojing， and the observation group was additionally treated with Xingnaojing injection combined with Xuesaitong soft capsules. After two-month treatment，the clinical effects，the vascular endothelial function including levels of thromboxane B2(TXB2)，endothelin(ET) and nitric oxide(NO)，and the scores of Chinese Stroke Scale(CSS) and Activities of Daily Living(ADL) in the two groups were observed and compared. Results：The total clinical effective rate was 97.4% in the observation group and 86.8% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of ET，TXB2 and NO between the two groups(P＞0.05). After treatment， the levels of ET and TXB2 in the two groups were decreased when compared with those before treatment(P＜ 0.05)， and the levels in the observation group were lower than those in the control group(P＜0.05)； NO levels in the two groups were increased when compared with those before treatment(P＜0.05)， and the level in the observation group was higher than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of scores of CSS and ADL between the two groups(P＞0.05). After treatment，the CSS scores in the two groups were decreased when compared with those before treatment(P＜0.05)， and the CSS score in the observation group was lower than that in the control group(P＜0.05)； ADL scores in the two groups were increased when compared with those before treatment(P＜0.05)，and the ADL score in the observation group was higher than that in the control group(P＜0.05). Conclusion：Xuesaitong soft capsules combined with Xingnaojing injection for transient ischemic attack has a better curative effect than that of simple Xingnaojing， which can significantly improve vascular endothelial function and nerve function defect，and enhance activities of daily living.