Abstract： Objective： To observe the curative effect of self- made Shugan Jianpi tang combined with routine western medicine for gastric ulcer of liver constraint and spleen deficiency type. Methods：A total of 86 cases of patients with gastric ulcer of liver constraint and spleen deficiency type were given a retrospective study，and divided into the observation group and the control group according to different treatment methods，with 43 cases in each group. The control group was given routine western medicine including amoxicillin，omeprazole and clarithromycin，and the observation group was treated with routine western medicine and Shugan Jianpi tang. Both groups were treated for four weeks. The clinical effects and Helicobacter pylori(Hp) clearance rates in the two groups were observed and compared. The changes in levels of gastrointestinal hormones including gastrin(GAS)， somatostatin(SS) and motilin(MTL) in serum in the two groups were detected. Results：The total clinical effective rate was 95.3% in the observation group and 79.1% in the control group，the difference being significant(P＜0.05). After treatment，the Hp clearance rate was 87.5% in the observation group and 56.7% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of gastrointestinal hormones including GAS， MTL and SS between the two groups(P＞ 0.05). After treatment， the levels of GAS and MTL in the two groups were decreased when compared with those before treatment(P＜0.05)，and the two indexes in the observation group were lower than those in the control group(P＜0.05)；the SS levels in the two groups were increased when compared with those before treatment(P＜0.05)，and the SS level in the observation group was higher than that in the control group(P＜0.05). Conclusion： The application of Shugan Jianpi tang combined with routine western medicine for gastric ulcer of liver constraint and spleen deficiency type can improve clinical effects，improve Hp clearance rates，and significantly improve levels of gastrointestinal hormones.