Abstract：Objective：To observe the clinical effect of Bushen Huoxue prescription combined with alendronate sodium in promoting osseointegration of dental implants in patients with osteoporosis(OP). Methods： A total of 63 cases of patients diagnosed as OP complicated with dental loss were divided into the experiment group and the control group according to the random number table method. After implantation， both groups were given routine treatment and alendronate sodium tablets，and the experiment group was additionally treated with Bushen Huoxue prescription. Both groups were treated for three months. Immediately after implantation， and one month and three months after implantation， the changes of bone mineral density and the monitoring of implant stability quotient(ISQ) were compared between the two groups. The occurrence of complications in dental implant and the medication safety within three months were observed. Results ： A total of 65 Straumann implants were implanted into the study subjects， with 100% implant survival rate. One month and three months after implantation，the bone mineral density in the two groups was higher than that at the previous time point(P＜ 0.05)，which showed an upward trend in bone mineral density. One month and three months after implantation，the bone mineral density values in the experiment group were higher than those in the control group，differences being significant(P＜ 0.05). One month and three months after implantation，the differences of ISQ values in the two groups were both significant when compared with those at the previous time point(P＜0.05). One month after implantation，the ISQ in the control group was decreased，and the ISQ in the experimental group was increased，the difference being significant(P＜0.05). There was no significant difference being found in the comparison of ISQ values between the two groups immediately after implantation and three months after implantation(P＞0.05). One patient in the control group had adverse reactions. Conclusion： Bushen Huoxue prescription combined with alendronate sodium can improve bone mineral density of OP patients，and at the same time promote osseointegration of dental implants and increase the implant stability at the early stage，which can be used as an adjuvant treatment after clinical dental implantation.