Abstract：Objective：To observe the effect of massage combined with Chinese medicine hot compress on the knee joint function，pain and swelling of knee joint，and quality of life of patients with knee osteoarthritis(KOA). Methods：A total of 117 cases of KOA patients were selected and divided into the study group and the control group according to the random number table method，with 59 and 58 cases in each group respectively. The control group was given block-therapy with 2% lidocaine hydrochloride and prednisolone acetate，and the study group was given massage combined with Chinese medicine hot compress on the basis of the control group. Both groups were treated for three weeks. The knee joint function， the degree of joint swelling， pain tolerance and quality of life before and after treatment， as well as clinical effects were compared between the two groups. Results： The total effective rate was 91.53% in the study group， higher than that of 77.59% in the control group(P＜0.05). After treatment， scores of the Western Ontario and McMaster Universities Arthritis Index(WOMAC) in the two groups were decreased when compared with those before treatment(P＜0.05)，the degree of joint swelling decreased(P＜0.05)，and the pain tolerance increased(P＜0.05). After treatment，WOMAC score in the study group was lower than that in the control group(P＜0.05)，the degree of joint swelling smaller(P＜0.05)，and the pain tolerance higher (P＜0.05). After treatment，the scores of general health，physiological function，physical role，social function，emotional function， bodily pain， vitality， and mental health in the two groups were increased when compared with those before treatment(P＜0.05)， and the general health， physiological functioning， physical role， social functioning， and bodily pain scores in the study group were higher than those in the control group(P＜0.05). Conclusion： The therapy of massage combined with Chinese medicine hot compress has a good curative effect in the treatment of KOA，which can improve the knee joint function，relieve joint pain and swelling，and enhance quality of life of patients.