Abstract： Objective： To systematically evaluate the efficacy and safety of Duhuo Jisheng Tang in the treatment of postmenopausal osteoporosis(PMOP). Methods：The databases of Wanfang，CNKI，VIP，CBM，PubMed，Embase，Web of Science and EBSCO were searched by computer. The literature of randomized controlled trials(RCTs) of Duhuo Jisheng Tang in the treatment of PMOP was included and the data were extracted. The literature quality was evaluated by Cochrane standard，and the software Revman5.4 was used for statistical analysis. Results：A total of 13 literatures，17 studies and 1 306 patients were included. The results of meta- analysis showed that Duhuo Jisheng Tang combined with western medicine increased clinical efficacy， lumbar bone mineral density， hip bone mineral density， femoral neck bone mineral density， estradiol， serum calcium and serum Osteocalcin(BGP). Reduce alkaline phosphatase， bone alkaline phosphatase and carboxy terminal peptide of type I collagen(β- CTX) is superior to western medicine.However， it has no obvious advantage over conventional western medicine in improving serum phosphorus level. Duhuo Jisheng Tang is superior to western medicine in increasing calcaneal bone mineral density，reducing serum BGP and bone alkaline phosphatase，and has no obvious advantages in other aspects. The adverse reactions were nausea，vomiting and other gastrointestinal reactions， which were relieved after symptomatic treatment. Conclusion：Compared with western medicine，Duhuo Jisheng Tang has certain advantages and high safety in increasing clinical efficacy， bone mineral density and estradiol level， but there is insufficient evidence in improving serum phosphorus level.